Journal article
Biological control of vertebrate pests using virally vectored immunocontraception
Journal of Reproductive Immunology, Vol.71(2), pp.102-111
2006
Abstract
Species-specific viruses are being genetically engineered to produce contraceptive biological controls for pest animals such as mice, rabbits and foxes. The virus vaccines are intended to trigger an autoimmune response in the target animals that interferes with their fertility in a process termed virally vectored immunocontraception. Laboratory experiments have shown that high levels of infertility can be induced in mice infected with recombinant murine cytomegalovirus and ectromelia virus expressing reproductive antigens as well as in rabbits using myxoma virus vectors. The strategies used to produce and deliver species-specific immunocontraceptive vaccines to free-living wildlife are presented in this review. Discussion includes coverage of the likely safety of the proposed vaccines as well as the implications of the approach for fertility control in other species.
Details
- Title
- Biological control of vertebrate pests using virally vectored immunocontraception
- Authors/Creators
- C.M. Hardy (Author/Creator) - Commonwealth Scientific and Industrial Research OrganisationL.A. Hinds (Author/Creator) - Commonwealth Scientific and Industrial Research OrganisationP.J. Kerr (Author/Creator) - Commonwealth Scientific and Industrial Research OrganisationM.L. Lloyd (Author/Creator) - The University of Western AustraliaA.J. Redwood (Author/Creator) - University of CanberraG.R. Shellam (Author/Creator) - The University of Western AustraliaT. Strive (Author/Creator) - Commonwealth Scientific and Industrial Research Organisation
- Publication Details
- Journal of Reproductive Immunology, Vol.71(2), pp.102-111
- Publisher
- Elsevier
- Identifiers
- 991005541143407891
- Copyright
- © 2006 Elsevier Ireland Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.81 Reproductive Biology
- 1.81.176 Male Fertility
- Web Of Science research areas
- Immunology
- Reproductive Biology
- ESI research areas
- Immunology