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Journal article
Biomarker changes with systolic anterior motion of the mitral valve in cats with hypertrophic cardiomyopathy
Journal of veterinary internal medicine, Vol.34(5), pp.1718-1727
2020
PMID: 32822105
Abstract
Background
N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin-I (cTnI) are biomarkers commonly evaluated in cats with suspected heart disease. Many cats with hypertrophic cardiomyopathy (HCM) have systolic anterior motion of the mitral valve (SAM), but its influence on circulating NT-proBNP or cTnI concentrations is currently unknown.
Hypothesis/Objectives
Cats with HCM and SAM (HCMSAM+) have higher NT-proBNP and cTnI concentrations than do cats with HCM but without SAM (HCMSAM−).
Animals
One hundred forty cats with HCM: 70 with SAM and 70 without SAM.
Methods
Retrospective case-to-case study. Cats were recruited if diagnosed with HCM by echocardiography and results were available for NT-proBNP or cTnI concentrations or both. Cats with SAM were matched to those without SAM for clinical presentation, left atrial (LA) size and left ventricular (LV) fractional shortening.
Results
A total of 119 NT-proBNP and 123 cTnI results were available. The HCMSAM+ cats had higher median concentrations than did HCMSAM− cats for NT-proBNP (729 pmoL/L; interquartile range [IQR], 275-1467 versus 65 pmoL/L; IQR, 25-271; P < .001) and cTnI (0.27 ng/mL; IQR, 0.10-0.81 versus 0.07 ng/mL; IQR, 0.01-0.43; P = .002). In general linear models for both NT-proBNP and cTnI, the independent explanatory variables were SAM, congestive heart failure, maximal LV wall thickness, and LA size.
Conclusions and Clinical Importance
For cats with HCM and equivalent LA size and LV systolic function, those with SAM had higher NT-proBNP and cTnI concentrations than did those without SAM. Presence of SAM should be considered when interpreting biomarker concentrations in cats with HCM.
Details
- Title
- Biomarker changes with systolic anterior motion of the mitral valve in cats with hypertrophic cardiomyopathy
- Authors/Creators
- Joonbum Seo - Clinical Science and Services, Royal Veterinary College, Hertfordshire, United KingdomJessie Rosie Payne - Langford Vets Small Animal Referral Hospital, University of Bristol, Bristol, United KingdomJose Novo Matos - Department of Veterinary Medicine, University of Cambridge, Cambridge, United KingdomWesley Wynne Fong - Clinical Science and Services, Royal Veterinary College, Hertfordshire, United KingdomDavid J. Connolly - Clinical Science and Services, Royal Veterinary College, Hertfordshire, United KingdomVirginia Luis Fuentes - Clinical Science and Services, Royal Veterinary College, Hertfordshire, United Kingdom
- Publication Details
- Journal of veterinary internal medicine, Vol.34(5), pp.1718-1727
- Publisher
- Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
- Number of pages
- 10
- Grant note
- Incentivo/EQB/LA0004/2013 / Fundação para a Ciência e a Tecnologia (http://data.elsevier.com/vocabulary/SciValFunders/501100001871) IDEXX Ltd
- Identifiers
- 991005912960207891
- Copyright
- © 2020 The Authors.
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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