Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk

Javier I Ottaviani; Abigail Britten; Debora Lucarelli; Robert Luben; Angela A Mulligan; Marleen A Lentjes; Reedmond Fong; Nicola Gray; Philip B Grace; Deborah H Mawson; Amy Tym; Antonia Wierzbicki; Nita G Forouhi; Kay-Tee Khaw; Hagen Schroeter; Gunter G C Kuhnle

doi:10.1038/s41598-020-74863-7

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Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk

Journal article

Open access

Peer reviewed

Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk

Javier I Ottaviani, Abigail Britten, Debora Lucarelli, Robert Luben, Angela A Mulligan, Marleen A Lentjes, Reedmond Fong, Nicola Gray, Philip B Grace, Deborah H Mawson, …

Scientific reports, Vol.10(1), 17964

2020

DOI: https://doi.org/10.1038/s41598-020-74863-7

PMCID: 7578063

PMID: 33087825

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Abstract

Aged

Blood Pressure

Cross-Sectional Studies

Eating - physiology

Feeding Behavior - physiology

Female

Flavonoids - administration & dosage

Heart Disease Risk Factors

Humans

Hypertension - physiopathology

Hypertension - prevention & control

Male

Melanesia

Middle Aged

Nutritional Physiological Phenomena - physiology

Flavan-3-ols are a group of bioactive compounds that have been shown to improve vascular function in intervention studies. They are therefore of great interest for the development of dietary recommendation for the prevention of cardio-vascular diseases. However, there are currently no reliable data from observational studies, as the high variability in the flavan-3-ol content of food makes it difficult to estimate actual intake without nutritional biomarkers. In this study, we investigated cross-sectional associations between biomarker-estimated flavan-3-ol intake and blood pressure and other CVD risk markers, as well as longitudinal associations with CVD risk in 25,618 participants of the European Prospective Investigation into Cancer (EPIC) Norfolk cohort. High flavan-3-ol intake, achievable as part of an habitual diet, was associated with a significantly lower systolic blood pressure (- 1.9 (- 2.7; - 1.1) mmHg in men and - 2.5 (- 3.3; - 1.8) mmHg in women; lowest vs highest decile of biomarker), comparable to adherence to a Mediterranean Diet or moderate salt reduction. Subgroup analyses showed that hypertensive participants had stronger inverse association between flavan-3-ol biomarker and systolic blood pressure when compared to normotensive participants. Flavanol intake could therefore have a role in the maintenance of cardiovascular health on a population scale.

Details

Title: Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk
Authors/Creators: Javier I Ottaviani - Mars (United States)
Abigail Britten - MRC Epidemiology Unit
Debora Lucarelli - MRC Epidemiology Unit
Robert Luben - University of Cambridge
Angela A Mulligan - MRC Epidemiology Unit
Marleen A Lentjes - Örebro University
Reedmond Fong - University of California, Davis
Nicola Gray - University of Reading
Philip B Grace - LGC, Newmarket Road, Fordham, UK
Deborah H Mawson - LGC, Newmarket Road, Fordham, UK
Amy Tym - LGC, Newmarket Road, Fordham, UK
Antonia Wierzbicki - LGC, Newmarket Road, Fordham, UK
Nita G Forouhi - MRC Epidemiology Unit
Kay-Tee Khaw - University of Cambridge
Hagen Schroeter - Mars (United States)
Gunter G C Kuhnle - University of Reading
Publication Details: Scientific reports, Vol.10(1), 17964
Publisher: Springer Nature
Grant note: MC_UU_12015/5 / Medical Research Council MC_UU_00006/3 / Medical Research Council IS-BRC-1215-20014 / Department of Health
Identifiers: 991005600059007891
Murdoch Affiliation: Centre for Computational and Systems Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.28 Antioxidant Activity
Web Of Science research areas: Nutrition & Dietetics
ESI research areas: Clinical Medicine