Bioreactor design for Tendon/Ligament engineering

T. Wang; B.S. Gardiner; Z. Lin; J. Rubenson; T.B. Kirk; A. Wang; J. Xu; D.W. Smith; D.G. Lloyd; M.H. Zheng

doi:10.1089/ten.TEB.2012.0295

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Bioreactor design for Tendon/Ligament engineering

Journal article

Peer reviewed

Bioreactor design for Tendon/Ligament engineering

T. Wang, B.S. Gardiner, Z. Lin, J. Rubenson, T.B. Kirk, A. Wang, J. Xu, D.W. Smith, D.G. Lloyd and M.H. Zheng

Tissue Engineering Part B: Reviews, Vol.19(2), pp.133-146

2013

DOI: https://doi.org/10.1089/ten.TEB.2012.0295

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Abstract

Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments.

Details

Title: Bioreactor design for Tendon/Ligament engineering
Authors/Creators: T. Wang (Author/Creator) - The University of Western Australia
B.S. Gardiner (Author/Creator) - School of Computer Science and Software Engineering
Z. Lin (Author/Creator) - School of Surgery
J. Rubenson (Author/Creator) - School of Sport Science, Exercise and Health
T.B. Kirk (Author/Creator) - Curtin University
A. Wang (Author/Creator) - School of Sport Science, Exercise and Health
J. Xu (Author/Creator) - School of Pathology and Laboratory Medicine
D.W. Smith (Author/Creator) - Software (Germany)
D.G. Lloyd (Author/Creator) - School of Sport Science, Exercise and Health
M.H. Zheng (Author/Creator) - School of Surgery
Publication Details: Tissue Engineering Part B: Reviews, Vol.19(2), pp.133-146
Publisher: Mary Ann Liebert Inc.
Identifiers: 991005542141307891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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