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Journal article
Blood biomarkers differentiate AD‐related versus non‐AD‐related cognitive deficits
Alzheimer's & dementia, Vol.21(3), e14619
2025
PMID: 40110626
Abstract
INTRODUCTION
The utility of blood-based biomarkers for discriminating Alzheimer's disease (AD)-related versus non-AD-related cognitive deficits in preclinical populations remains poorly understood. Here, we tested the capability of blood markers to detect and discriminate variation in performance across multiple cognitive domains in a cognitively unimpaired sample.
METHODS
Participants (n = 648, aged 69.9 ± 3.8, 71% female) underwent a comprehensive cognitive assessment and assays for plasma-based biomarkers amyloid beta (Aβ)1-42/1-40 by mass spectrometry, phosphorylated tau (p-tau) 181 and 217, p-tau217/Aβ1-42, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL).
RESULTS
Greater p-tau217 was exclusively associated with poorer episodic memory performance (β = −0.11, SE = 0.04, p = .003), and remained so after covarying for NfL. Higher NfL was non-specifically associated with poorer performance across a range of cognitive domains and remained so after covarying for p-tau217.
DISCUSSION
Blood-based biomarkers may differentiate non-AD-related versus AD-related cognitive deficits. This characterization will be important for early intervention and disease monitoring for AD.
Details
- Title
- Blood biomarkers differentiate AD‐related versus non‐AD‐related cognitive deficits
- Authors/Creators
- Kelsey R. Sewell - Neuroscience Murdoch UniversityLauren E. Oberlin - Weill Cornell MedicineThomas K. Karikari - University of PittsburghMarcos Olvera-Rojas - Universidad de GranadaLu Wan - NeuroscienceJill K. Morris - University of Kansas Medical CenterPaul J. Kueck - University of KansasXuemei Zeng - University of PittsburghHaiqing Huang - NeuroscienceGeorge Grove - University of PittsburghYijun Chen - University of PittsburghTara K. Lafferty - University of PittsburghAnuradha Sehrawat - University of PittsburghM. Ilyas Kamboh - University of PittsburghAnna L. Marsland - University of PittsburghArthur F. Kramer - Northeastern University University of Illinois at Urbana Champaign Northeastern UniversityEdward McAuley - University of Illinois Urbana-ChampaignJeffrey M. Burns - Alzheimer’s Disease Neuroimaging InitiativeCharles H. Hillman - Northeastern UniversityEric D. Vidoni - University of Kansas Medical CenterChaeryon Kang - University of PittsburghKirk I. Erickson - University of Pittsburgh
- Publication Details
- Alzheimer's & dementia, Vol.21(3), e14619
- Publisher
- John Wiley and Sons Inc.; HOBOKEN
- Number of pages
- 10
- Grant note
- P30 AG072973; UL1TR002366 / Kansas University infrastructure
- Identifiers
- 991005753926407891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior