Logo image
Back
Bone mineral density, adiposity, and cognitive functions
Journal article   Open access   Peer reviewed

Bone mineral density, adiposity, and cognitive functions

H.R. Sohrabi, K.A. Bates, M. Weinborn, R.S. Bucks, S.R. Rainey-Smith, M.A. Rodrigues, S.M. Bird, B.M. Brown, J. Beilby, M. Howard, …
Frontiers in Aging Neuroscience, Vol.7, Article 16
2015
DOI: https://doi.org/10.3389/fnagi.2015.00016
pdf
bone_mineral_density.pdfDownloadView
Published (Version of Record) Open Access
url
Free to Read *No subscription requiredView

Abstract

Cognitive decline and dementia due to Alzheimer's disease (AD) have been associated with genetic, lifestyle, and environmental factors. A number of potentially modifiable risk factors should be taken into account when preventive or ameliorative interventions targeting dementia and its preclinical stages are investigated. Bone mineral density (BMD) and body composition are two such potentially modifiable risk factors, and their association with cognitive decline was investigated in this study. 164 participants, aged 34–87 years old (62.78 ± 9.27), were recruited for this longitudinal study and underwent cognitive and clinical examinations at baseline and after 3 years. Blood samples were collected for apolipoprotein E (APOE) genotyping and dual energy x-ray absorptiometry (DXA) was conducted at the same day as cognitive assessment. Using hierarchical regression analysis, we found that BMD and lean body mass, as measured using DXA were significant predictors of episodic memory. Age, gender, APOE status, and premorbid IQ were controlled for. Specifically, the List A learning from California Verbal Learning Test was significantly associated with BMD and lean mass both at baseline and at follow up assessment. Our findings indicate that there is a significant association between BMD and lean body mass and episodic verbal learning. While the involvement of modifiable lifestyle factors in human cognitive function has been examined in different studies, there is a need for further research to understand the potential underlying mechanisms.

Details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Metrics

131 File views/ downloads
49 Record Views
24 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
International collaboration
Citation topics
1 Clinical & Life Sciences
1.80 Bone Diseases
1.80.41 Osteoporosis
Web Of Science research areas
Geriatrics & Gerontology
Neurosciences
ESI research areas
Neuroscience & Behavior
Logo image