Journal article
Boron-based drugs as antiprotozoals
Current Opinion in Infectious Diseases, Vol.24(6), pp.586-592
2011
Abstract
PURPOSE OF REVIEW: Boron-based drugs represent a new class of molecules that have been found to exhibit attractive properties and activities against a number of protozoans causative of neglected tropical diseases. RECENT FINDINGS: This review highlights recent advances in discovery of potential treatments for human African trypanosomiasis, malaria and Chagas disease from a class of boron-containing drugs, the benzoxaboroles. SUMMARY: Research at several biotechnology companies, sponsored by product development partners (PDPs), has been successful in identifying a novel class of boron-based drugs, the benzoxaboroles, as potential treatments for neglected tropical diseases. This work was based, in part, on the earlier observation of antifungal, antibacterial and anti-inflammatory activities of the benzoxaboroles. The unique properties of boron, namely its ability to reversibly interact with biochemical targets through an empty p-orbital, are important to the success of these new drug candidates. Physicochemical and pharmacokinetic properties of the boron-based compounds are consistent with features required for oral absorption, metabolic stability and low toxicity - all important for progression of this class to clinical trials.
Details
- Title
- Boron-based drugs as antiprotozoals
- Authors/Creators
- R.T. Jacobs (Author/Creator)J.J. Plattner (Author/Creator)M. Keenan (Author/Creator)
- Publication Details
- Current Opinion in Infectious Diseases, Vol.24(6), pp.586-592
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Identifiers
- 991005542059907891
- Copyright
- © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.261 Parasitology - Trypanosoma & Leishmania
- 1.261.596 Trypanosoma Biology
- Web Of Science research areas
- Infectious Diseases
- ESI research areas
- Immunology