Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Yaqing Shu; Youming Long; Shisi Wang; Wanming Hu; Jian Zhou; Huiming Xu; Chen Chen; Yangmei Ou; Zhengqi Lu; Alexander Y Lau; Xinhua Yu; Allan G Kermode; Wei Qiu

doi:10.1002/acn3.712

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Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Journal article

Open access

Peer reviewed

Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Yaqing Shu, Youming Long, Shisi Wang, Wanming Hu, Jian Zhou, Huiming Xu, Chen Chen, Yangmei Ou, Zhengqi Lu, Alexander Y Lau, …

Annals of clinical and translational neurology, Vol.6(2), pp.392-396

2019

DOI: https://doi.org/10.1002/acn3.712

PMCID: PMC6389737

PMID: 30847372

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Abstract

Autoantibodies - adverse effects

Demyelinating Diseases - chemically induced

Demyelinating Diseases - diagnosis

Demyelinating Diseases - pathology

Encephalomyelitis - drug therapy

Encephalomyelitis - pathology

Humans

Immunologic Factors - metabolism

Male

Middle Aged

Multiple Sclerosis - drug therapy

Multiple Sclerosis - pathology

Myelin-Associated Glycoprotein - metabolism

Myelin-Oligodendrocyte Glycoprotein - metabolism

Nervous System Malformations - drug therapy

Nervous System Malformations - pathology

Oligodendroglia - drug effects

Oligodendroglia - metabolism

Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.

Details

Title: Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor
Authors/Creators: Yaqing Shu - Third Affiliated Hospital of Sun Yat-sen University
Youming Long - Second Affiliated Hospital of Guangzhou Medical University
Shisi Wang - Third Affiliated Hospital of Sun Yat-sen University
Wanming Hu - Sun Yat-sen University
Jian Zhou - Sun Yat-sen University
Huiming Xu - Second Affiliated Hospital of Guangzhou Medical University
Chen Chen - Third Affiliated Hospital of Sun Yat-sen University
Yangmei Ou - Department of Neurology 999 brain hospital Guangzhou 510510 China
Zhengqi Lu - Third Affiliated Hospital of Sun Yat-sen University
Alexander Y Lau - Chinese University of Hong Kong
Xinhua Yu - German Center for Lung Research
Allan G Kermode - Perron Institute for Neurological and Translational Science
Wei Qiu - Third Affiliated Hospital of Sun Yat-sen University
Publication Details: Annals of clinical and translational neurology, Vol.6(2), pp.392-396
Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association.
Identifiers: 991005624463107891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior