Journal article
Brain immunohistopathology in a patient with autoimmune Glial Fibrillary acidic protein astrocytopathy
Neuroimmunomodulation, Vol.25(1), pp.1-6
2018
Abstract
Background: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel meningoencephalomyelitis. However, the pathogenesis of this disease is unclear. We therefore examined a brain biopsy from a patient with autoimmune GFAP astrocytopathy by immunohistopathology. Methods: We examined brain biopsy sections from a patient with autoimmune GFAP astrocytopathy using hematoxylin and eosin (HE) and Luxol fast blue (LFB) staining, and immunostaining with antibodies for CD4, CD8, CD3, CD20, CD68, CD138, Neu-N, GFAP, myelin oligodendrocyte glycoprotein (MOG), and aquaporin-4 (AQP4). Results: HE staining revealed extensive inflammatory cells (marked lymphocytes) around brain vessels, and LFB showed no signs of demyelination or axon loss. Immunohistochemical analysis showed CD3+ and CD4+ T cells cuffing around brain vessels, accompanied by CD8+ T cells, CD20+ B cells, and CD138+ plasma cells, while some macrophages (CD68+) were scattered throughout the brain parenchyma. There was no loss of AQP4 or MOG expression in this patient, while GFAP was abundantly expressed. Conclusions: These findings suggest that inflammatory cells, including T cells, B cells, plasma cells, and macrophages, are involved in autoimmune GFAP astrocytopathy. Demyelination and astrocyte loss may not necessarily occur in this disease.
Details
- Title
- Brain immunohistopathology in a patient with autoimmune Glial Fibrillary acidic protein astrocytopathy
- Authors/Creators
- Y. Shu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Long (Author/Creator) - Second Affiliated Hospital of Guangzhou Medical UniversityY. Chang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityR. Li (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityX. Sun (Author/Creator)Y. Wang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Huang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityJ. Li (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityJ. Chen (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Yang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityZ. Lu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityX. Hu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityA.G. Kermode (Author/Creator) - a,dW. Qiu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
- Publication Details
- Neuroimmunomodulation, Vol.25(1), pp.1-6
- Publisher
- Karger
- Identifiers
- 991005541789507891
- Copyright
- © 2018 S. Karger AG, Basel
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.1602 Limbic Encephalitis
- Web Of Science research areas
- Endocrinology & Metabolism
- Immunology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior