Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis

A.G. Kermode; A.J. Thompson; P.S. Tofts; D.G. MacManus; B.E. Kendall; D.P.E. Kingsley; I.F. Moseley; P. Rudge; W.I. McDonald

doi:10.1093/brain/113.5.1477

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Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis

Journal article

Peer reviewed

Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis

A.G. Kermode, A.J. Thompson, P.S. Tofts, D.G. MacManus, B.E. Kendall, D.P.E. Kingsley, I.F. Moseley, P. Rudge and W.I. McDonald

Brain, Vol.113(5), pp.1477-1489

1990

DOI: https://doi.org/10.1093/brain/113.5.1477

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Abstract

From an extensive serial magnetic resonance imaging (MRI) study in multiple sclerosis (MS) we have identified 4 cases in which disruption of the blood-brain barrier, as detected by gadolinium-DTPA enhancement, preceded other MRI abnormalities and in 1 case clinical evidence of the new lesion. This supports the view that a defect in the blood-brain barrier, and therefore inflammation, is an early and possibly crucial event in the pathogenesis of the new lesion in MS. These cases showed a marked discrepancy between MRI abnormality and symptoms. The mechanisms contributing to this disparity are discussed, and it is concluded that far from being surprising it is to be expected.

Details

Title: Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis
Authors/Creators: A.G. Kermode (Author/Creator) - Multiple Sclerosis NMR Research Group, Institute of Neurology, London, UK.
A.J. Thompson (Author/Creator) - The Multiple Sclerosis NMR Research Group, Institute of NeurologyLondon, UK
P.S. Tofts (Author/Creator) - The Multiple Sclerosis NMR Research Group, Institute of NeurologyLondon, UK
D.G. MacManus (Author/Creator) - The Multiple Sclerosis NMR Research Group, Institute of NeurologyLondon, UK
B.E. Kendall (Author/Creator) - The National Hospitals for Nervous Diseases, Queen SquareLondon, UK
D.P.E. Kingsley (Author/Creator) - The National Hospitals for Nervous Diseases, Queen SquareLondon, UK
I.F. Moseley (Author/Creator) - The National Hospitals for Nervous Diseases, Queen SquareLondon, UK
P. Rudge (Author/Creator) - The Multiple Sclerosis NMR Research Group, Institute of NeurologyLondon, UK
W.I. McDonald (Author/Creator) - The Multiple Sclerosis NMR Research Group, Institute of NeurologyLondon, UK
Publication Details: Brain, Vol.113(5), pp.1477-1489
Publisher: Oxford University Press
Identifiers: 991005540136207891
Copyright: © 1990 Oxford University Press
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior