Journal article
CCR5-Δ32 genotype does not improve predictive value of IL28B polymorphisms for treatment response in chronic HCV infection
Genes and Immunity, Vol.14(5), pp.286-290
2013
Abstract
IL28B polymorphisms strongly predict spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection. A recent study proposed a 32-base pair deletion in the CC-chemokine receptor 5 (CCR5) gene (CCR5-Δ32) interacting with the IL28B polymorphisms to influence spontaneous HCV clearance. The aim of this study was to clarify the role of CCR5-Δ32 in treatment-induced clearance of chronic hepatitis C (CHC). A cross-sectional cohort of 813 Caucasian patients with CHC genotype 1 (365 responders and 448 non-responders) who had received standard of care dual therapy with interferon (IFN)-α and ribavirin (RBV) was genotyped for the CCR5-Δ32 and IL28B polymorphisms to examine their interaction with respect to treatment response. CCR5-Δ32 did not influence treatment-induced recovery to IFN-α/RBV in CHC, and did not improve prediction of sustained virological response in the context of the IL28B polymorphisms in a multivariate model. CCR5-Δ32 homozygotes were significantly more frequent in those with CHC than healthy controls in the European cohorts (2.9% vs 0.4%, P<0.0001), but not in Australians of European ancestry. In conclusion, CCR5-Δ32 does not influence treatment response in the context of IL28B polymorphisms. Although CCR5-Δ32 may affect viral clearance within closely controlled geographical and genetic environments, we found no effect in larger cohorts treated with dual therapy.
Details
- Title
- CCR5-Δ32 genotype does not improve predictive value of IL28B polymorphisms for treatment response in chronic HCV infection
- Authors/Creators
- V. Suppiah (Author/Creator)N.J. Armstrong (Author/Creator)K.S. O'Connor (Author/Creator)T. Berg (Author/Creator)M. Weltman (Author/Creator)M.L. Abate (Author/Creator)U. Spengler (Author/Creator)M. Bassendine (Author/Creator)G.J. Dore (Author/Creator)W.L. Irving (Author/Creator)E. Powell (Author/Creator)J. Nattermann (Author/Creator)T. Mueller (Author/Creator)S. Riordan (Author/Creator)G.J. Stewart (Author/Creator)J. George (Author/Creator)D.R. Booth (Author/Creator)G. Ahlenstiel (Author/Creator)M. Michalk (Author/Creator)B. Malik (Author/Creator)P. McClure (Author/Creator)S. Smith (Author/Creator)D. Sheridan (Author/Creator)E. Snape (Author/Creator)V. Fragomeli (Author/Creator)R. Norris (Author/Creator)D. How-Chow (Author/Creator)J.R. Jonsson (Author/Creator)H. Barrie (Author/Creator)S. Stelzer-Braid (Author/Creator)S. Fletcher (Author/Creator)T. Applegate (Author/Creator)J. Grebely (Author/Creator)G. Matthews (Author/Creator)M. Bharadwaj (Author/Creator)A. Smedile (Author/Creator)
- Publication Details
- Genes and Immunity, Vol.14(5), pp.286-290
- Publisher
- Nature Publishing Group
- Identifiers
- 991005543310007891
- Copyright
- © 2013 Macmillan Publishers Limited
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.83 HCV
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Molecular Biology & Genetics