Journal article
CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation
Hepatology, Vol.47(2), pp.396-406
2008
Abstract
Hepatitis C virus (HCV) causes chronic infection accompanied by a high risk of liver failure and hepatocellular carcinoma. CD8+ T cell responses are important in the control of viremia. However, the T cell response in chronic infection is weak both in absolute numbers and in the range of epitopes targeted. In order to explore the biology of this response further, we analyzed expression of a panel of natural killer cell markers in HCV compared with other virus-specific T cell populations as defined by major histocompatibility complex class I tetramers. We found that CD161 was significantly expressed on HCV-specific cells (median 16.8%) but not on CD8+ T cells specific for human immunodeficiency virus (3.3%), cytomegalovirus (3.4%), or influenza (3.4%). Expression was seen in acute, chronic, and resolved disease and was greatest on intrahepatic HCV-specific T cells (median 57.6%; P < 0.05). Expression of CD161 was also found on hepatitis B virus–specific CD8+ T cells. In general, CD161+CD8+ T cells were found to be CCR7− “effector memory” T cells that could produce proinflammatory cytokines (interferon-γ and tumor necrosis factor-α) but contained scanty amounts of cytolytic molecules (granzyme B and perforin) and proliferated poorly in vitro. Expression of CD161 on CD8+ T cells was tightly linked to that of CXCR6, a chemokine with a major role in liver homing. Conclusion: We propose that expression of CD161 indicates a unique pattern of T cell differentiation that might help elucidate the mechanisms of HCV immunity and pathogenesis.
Details
- Title
- CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation
- Authors/Creators
- J.W. Northfield (Author/Creator) - Medawar Building for Pathogen ResearchV. Kasprowicz (Author/Creator) - Partners AIDS Research Group, Charlestown, MAM. Lucas (Author/Creator) - Royal Perth HospitalN. Kersting (Author/Creator) - University of FreiburgB. Bengsh (Author/Creator) - University of FreiburgA. Kim (Author/Creator) - Partners AIDS Research Group, Charlestown, MAR.E. Phillips (Author/Creator) - Medawar Building for Pathogen ResearchB.D. Walker (Author/Creator) - Partners AIDS Research Group, Charlestown, MAR. Thimme (Author/Creator) - University of FreiburgG. Lauer (Author/Creator) - Partners AIDS Research Group, Charlestown, MAP. Klenerman (Author/Creator) - Medawar Building for Pathogen Research
- Publication Details
- Hepatology, Vol.47(2), pp.396-406
- Publisher
- Wiley
- Identifiers
- 991005542660707891
- Copyright
- © American Association for the Study of Liver Diseases
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.1021 Natural Killer Cells
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine