COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults

T. Porter; S.C. Burnham; L. Milicic; G. Savage; P. Maruff; H.R. Sohrabi; M. Peretti; Y.Y. Lim; M. Weinborn; D. Ames; C.L. Masters; R.N. Martins; S. Rainey-Smith; C.C. Rowe; O. Salvado; D. Groth; G. Verdile; V.L. Villemagne; S.M. Laws

doi:10.1016/j.ibror.2019.05.001

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COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults

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COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults

T. Porter, S.C. Burnham, L. Milicic, G. Savage, P. Maruff, H.R. Sohrabi, M. Peretti, Y.Y. Lim, M. Weinborn, D. Ames, …

IBRO Reports, Vol.6, pp.147-152

2019

DOI: https://doi.org/10.1016/j.ibror.2019.05.001

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Abstract

The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer’s disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aβ-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.

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Title: COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults
Authors/Creators: T. Porter (Author/Creator)
S.C. Burnham (Author/Creator) - Edith Cowan University
L. Milicic (Author/Creator) - Edith Cowan University
G. Savage (Author/Creator) - Macquarie University
P. Maruff (Author/Creator) - Florey Institute of Neuroscience and Mental Health
H.R. Sohrabi (Author/Creator) - Edith Cowan University
M. Peretti (Author/Creator) - Edith Cowan University
Y.Y. Lim (Author/Creator) - Florey Institute of Neuroscience and Mental Health
M. Weinborn (Author/Creator) - The University of Western Australia
D. Ames (Author/Creator) - St Vincent's Health
C.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental Health
R.N. Martins (Author/Creator) - Edith Cowan University
S. Rainey-Smith (Author/Creator) - Edith Cowan University
C.C. Rowe (Author/Creator) - Austin Health
O. Salvado (Author/Creator) - CSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston 4029, Queensland, Australia
D. Groth (Author/Creator) - Curtin University
G. Verdile (Author/Creator) - Edith Cowan University
V.L. Villemagne (Author/Creator) - Austin Health
S.M. Laws (Author/Creator) - Edith Cowan University
Publication Details: IBRO Reports, Vol.6, pp.147-152
Publisher: Elsevier Ltd on behalf of International Brain Research Organization
Identifiers: 991005542880507891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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