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Journal article
Can digital mobility assessment enhance the clinical assessment of disease severity in Parkinson’s Disease?
Journal of Parkinson's disease, Vol.13(6), pp.999-1009
2023
Abstract
Background: Real-world walking speed (RWS) measured using wearable devices has the potential to complement the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS III) for motor assessment in Parkinson’s disease (PD). Objective: Explore cross-sectional and longitudinal differences in RWS between PD and older adults (OAs), and whether RWS was related to motor disease severity cross-sectionally, and if MDS-UPDRS III was related to RWS, longitudinally. Methods: 88 PD and 111 OA participants from ICICLE-GAIT (UK) were included. RWS was evaluated using an accelerometer at four time points. RWS was aggregated within walking bout (WB) duration thresholds. Between-group-comparisons in RWS between PD and OAs were conducted cross-sectionally, and longitudinally with mixed effects models (MEMs). Cross-sectional association between RWS and MDS-UPDRS III was explored using linear regression, and longitudinal association explored with MEMs. Results: RWS was significantly lower in PD (1.04 m/s) in comparison to OAs (1.10 m/s) cross-sectionally. RWS significantly decreased over time for both cohorts and decline was more rapid in PD by 0.02 m/s per year. Significant negative relationship between RWS and the MDS-UPDRS III only existed at a specific WB threshold (30 to 60 s, β= – 3.94 points, p = 0.047). MDS-UPDRS III increased significantly by 1.84 points per year, which was not related to change in RWS. Conclusion: Digital mobility assessment of gait may add unique information to quantify disease progression remotely, but further validation in research and clinical settings is needed.
Details
- Title
- Can digital mobility assessment enhance the clinical assessment of disease severity in Parkinson’s Disease?
- Authors/Creators
- Cameron Kirk - Newcastle UniversityRana Zia Ur Rehman - Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK, Janssen Research & Development, High Wycombe, UKBrook Galna - Murdoch University, Centre for Healthy AgeingLisa Alcock - Newcastle UniversitySaverio Ranciati - University of BolognaLuca Palmerini - Laboratori Guglielmo Marconi (Italy)Judith Garcia-Aymerich - Barcelona Institute for Global HealthClint Hansen - Christian-Albrechts-Universität zu KielEva Schaeffer - Christian-Albrechts-Universität zu KielDaniela Berg - Christian-Albrechts-Universität zu KielWalter Maetzler - Christian-Albrechts-Universität zu KielLynn Rochester - Newcastle UniversitySilvia Del Din - Newcastle UniversityAlison J. Yarnall - Newcastle University
- Publication Details
- Journal of Parkinson's disease, Vol.13(6), pp.999-1009
- Publisher
- IOS Press
- Identifiers
- 991005605568407891
- Copyright
- © 2023 – The authors.
- Murdoch Affiliation
- School of Allied Health
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.263 Gait and Balance
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior