Journal article
Capsaicin-induced death of human haematological malignant cell lines is independent of TRPV1 activation
Pharmacology, Vol.98(1-2), pp.79-86
2016
Abstract
The effect of the plant-derived vanilloid, capsaicin (CAP), on the metabolic activity of THP-1, U266B1 and U937 hematological malignancy cells was determined. CAP reduced metabolic activity in a concentration-dependent manner in the three cell lines. A biphasic effect was observed on THP-1 cells (EC50: IC50 (95% CI) 32.9 (19.9-54.3)/219 (144-246) µmol/l). U266B1 cells were more resistant to CAP than THP-1 and U937. Metabolic activity was significantly inhibited by CAP in U937 compared to U266B1 cells (IC50: 197 versus 431 µmol/l, respectively, p < 0.008). Transient receptor potential vanilloid-1 (TRPV1) and CB1 antagonists (SB452533 and AM251, respectively) suppressed the CAP-induced increase in THP-1 cell metabolic activity (p < 0.001). AM251 and SB452533 appeared to act as partial agonists and displayed a synergistic effect with CAP in U937 cells. CAP inhibits the metabolic activity of malignant hematological cells through non-TRPV1-dependent mechanisms.
Details
- Title
- Capsaicin-induced death of human haematological malignant cell lines is independent of TRPV1 activation
- Authors/Creators
- S.A. Omari (Author/Creator) - University of TasmaniaM.J. Adams (Author/Creator)D.A. Kunde (Author/Creator)D.P. Geraghty (Author/Creator)
- Publication Details
- Pharmacology, Vol.98(1-2), pp.79-86
- Publisher
- Karger Publishers
- Identifiers
- 991005541535107891
- Copyright
- © 2016 S. Karger AG, Basel
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.79 Molecular & Cell Biology - Physiology
- 1.79.1259 TRP Channel Functions
- Web Of Science research areas
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology