Carbohydrates in Human Milk and Body Composition of Term Infants during the First 12 Months of Lactation

Zoya Gridneva; Alethea Rea; Wan Jun Tie; Ching Tat Lai; Sambavi Kugananthan; Leigh C Ward; Kevin Murray; Peter E Hartmann; Donna T Geddes

doi:10.3390/nu11071472

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Carbohydrates in Human Milk and Body Composition of Term Infants during the First 12 Months of Lactation

Journal article

Open access

Peer reviewed

Carbohydrates in Human Milk and Body Composition of Term Infants during the First 12 Months of Lactation

Zoya Gridneva, Alethea Rea, Wan Jun Tie, Ching Tat Lai, Sambavi Kugananthan, Leigh C Ward, Kevin Murray, Peter E Hartmann and Donna T Geddes

Nutrients, Vol.11(7), 1472

2019

DOI: https://doi.org/10.3390/nu11071472

PMCID: PMC6683013

PMID: 31261649

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Abstract

Adiposity

Age Factors

Body Composition

Breast Feeding

Child Development

Dietary Carbohydrates - metabolism

Female

Humans

Infant

Infant Nutritional Physiological Phenomena

Lactation

Longitudinal Studies

Male

Milk, Human - metabolism

Nutritional Status

Nutritive Value

Pilot Projects

Proof of Concept Study

Human milk (HM) carbohydrates may affect infant appetite regulation, breastfeeding patterns, and body composition (BC). We investigated relationships between concentrations/calculated daily intakes (CDI) of HM carbohydrates in first year postpartum and maternal/term infant BC, as well as breastfeeding parameters. BC of dyads (= 20) was determined at 2, 5, 9, and/or 12 months postpartum using ultrasound skinfolds (infants) and bioelectrical impedance spectroscopy (infants/mothers). Breastfeeding frequency, 24-h milk intake and total carbohydrates (TCH) and lactose were measured to calculate HM oligosaccharides (HMO) concentration and CDI of carbohydrates. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Higher TCH concentrations were associated with greater infant length, weight, fat-free mass (FFM), and FFM index (FFMI), and decreased fat mass (FM), FM index (FMI), %FM and FM/FFM ratio. Higher HMO concentrations were associated with greater infant FFM and FFMI, and decreased FMI, %FM, and FM/FFM ratio. Higher TCH CDI were associated with greater FM, FMI, %FM, and FM/FFM ratio, and decreased infant FFMI. Higher lactose CDI were associated with greater FM, FMI, %FM, and FM/FFM, ratio and decreased FFMI. Concentrations and intakes of HM carbohydrates differentially influence development of infant BC in the first 12 months postpartum, and may potentially influence risk of later obesity via modulation of BC.

Details

Title: Carbohydrates in Human Milk and Body Composition of Term Infants during the First 12 Months of Lactation
Authors/Creators: Zoya Gridneva - The University of Western Australia
Alethea Rea - The University of Western Australia
Wan Jun Tie - The University of Western Australia
Ching Tat Lai - The University of Western Australia
Sambavi Kugananthan - The University of Western Australia
Leigh C Ward - The University of Queensland
Kevin Murray - The University of Western Australia
Peter E Hartmann - The University of Western Australia
Donna T Geddes - The University of Western Australia
Publication Details: Nutrients, Vol.11(7), 1472
Publisher: MDPI
Grant note: unrestricted research grant / Medela AG Margaret Lomann-Hall Scholarship from the School of Human Sciences / The University of Western Australia Australian Postgraduate Award / The University of Western Australia
Identifiers: 991005580045707891
Murdoch Affiliation: School of Mathematics, Statistics, Chemistry and Physics; Centre for Terrestrial Ecosystem Science and Sustainability
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.72 Obstetrics & Gynecology; 1.72.891 Breastfeeding
Web Of Science research areas: Nutrition & Dietetics
ESI research areas: Agricultural Sciences