Journal article
Cardiovascular autonomic dysfunction in a novel rodent model of polycystic kidney disease
Autonomic Neuroscience, Vol.152(1-2), pp.60-66
2010
Abstract
Autonomic dysfunction, hypertension and cardiovascular morbidity in end stage renal disease are critically linked, however there are limited models available to investigate this relationship and develop clinical interventions. This study aimed to define the relationship between hypertension and autonomic function in a new rodent model of polycystic kidney disease (PKD). Using measures of heart rate and systolic blood pressure variability (HRV, SBPV), and time domain analysis of cardiac and sympathetic baroreflex function, we compared the Lewis PKD model (LPK) to a Lewis control. Systolic BP and SBPV were significantly higher in LPK vs. Lewis (168 ± 7 vs. 131 ± 8 mm Hg, P ≤ 0.01, total power: 11 ± 3.1 vs. 1.3 ± 0.3 mm Hg/Hz2, P ≤ 0.05). LPK has a higher resting HR (437 ± 17 vs. 330 ± 11 beats per minute [bpm], P ≤ 0.001) associated with reduced HRV (total power [1.7 ± 0.3 vs. 4.6 ± 1.1 ms/Hz2, P ≤ 0.01]). Atenolol decreased HR to a greater extent in the LPK (90 ± 10 vs. 20 ± 17 bpm, P ≤ 0.001) while subsequent methylatropine administration produced a greater increase in Lewis HR (24 ± 9 vs. 66 ± 9 bpm, P ≤ 0.01). No difference in intrinsic HR following both drugs existed. Cardiac baroreflex function was impaired in LPK vs. Lewis (0.6 ± 0.4 vs. 1.2 ± 0.2 bpm/mm Hg P ≤ 0.05, and 0.3 ± 0.1 vs. 3.1 ± 0.6 ms/mm Hg, P ≤ 0.001, respectively). The sympathetic baroreflex function curve was shifted upwards and towards the right in LPK (P ≤ 0.01). Sympathetic baroreflex gain was not altered. This data suggests that sympathetic hyperactivity and reduced vagal function underlies the hypertension and reduced cardiac baroreflex function in the LPK model.
Details
- Title
- Cardiovascular autonomic dysfunction in a novel rodent model of polycystic kidney disease
- Authors/Creators
- J.L. Harrison (Author/Creator)C.M. Hildreth (Author/Creator)S. Callahan (Author/Creator)A.K. Goodchild (Author/Creator)J.K. Phillips (Author/Creator)
- Publication Details
- Autonomic Neuroscience, Vol.152(1-2), pp.60-66
- Publisher
- Elsevier
- Identifiers
- 991005541489807891
- Copyright
- © 2009 Elsevier B.V.
- Murdoch Affiliation
- Integrated Health Institute; School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.218 Autonomic Regulation
- 1.218.642 Heart Rate Variability
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior