Journal article
Cardiovascular effects of two adenosine constant rate infusions in anaesthetised dogs
Veterinary Anaesthesia and Analgesia, Vol.46(3), pp.289-298
2019
Abstract
Objective
Adenosine induces vasodilatation. The aim of this study was to investigate cardiovascular effects of two adenosine constant rate infusion (CRI) doses in dogs.
Study design
Experimental, longitudinal repeated measure design
Animals
Ten healthy purpose-bred Beagle dogs
Methods
Each dog was sedated with butorphanol. Anaesthesia was induced with propofol intravenously (IV) and maintained with sevoflurane [inspired oxygen fraction (FIO2) = 47-55%]. Controlled mechanical ventilation was used to maintain normocapnia. Each dog received two consecutive adenosine CRIs: 140 μg kg-1 minute-1 (A140) followed by 280 μg kg-1 minute-1 (A280). Pulse rate (PR), invasive arterial pressure and stroke volume [SVMRT; by magnetic resonance phase contrast angiography (Q-Flow)] were measured at baseline, 3 minutes after starting adenosine and 3 and 10 minutes after discontinuing adenosine. Cardiac output (CO), cardiac index (CI) and approximated systemic vascular resistances (approximate SVR) were calculated. Additionally, arterial blood gases, co-oximetry, electrolytes, glucose and lactate were measured and oxygen content (CaO2) and delivery (DO2) calculated. One-way repeated measures ANOVA (p < 0.05) was used for data analysis.
Results
A140 and A280 resulted in a significant decrease in arterial blood pressure (systolic arterial pressure (SAP) (p = 0.008), mean arterial pressure (MAP) (p = 0.003) and diastolic arterial pressure (DAP) (p = 0.004)) and approximate SVR (p = 0.008) compared to baseline. No significant changes were detected for the other variables. All values returned to baseline within 3 minutes after adenosine discontinuation.
Conclusions
and clinical relevance Adenosine CRI decreases arterial pressure by vasodilatation in healthy dogs. No additional effects were observed with the higher dose. The effects in compromised dogs remain to be investigated.
Keywords: adenosine;;anaesthesia; cardiovascular; cMRI; dog
Details
- Title
- Cardiovascular effects of two adenosine constant rate infusions in anaesthetised dogs
- Authors/Creators
- F.B. Joerger (Author/Creator)M. Dennler (Author/Creator)C. Meira (Author/Creator)M. Mosing (Author/Creator)H. Richter (Author/Creator)S.K. Ringer (Author/Creator)
- Publication Details
- Veterinary Anaesthesia and Analgesia, Vol.46(3), pp.289-298
- Publisher
- Elsevier Ltd.
- Identifiers
- 991005540523307891
- Copyright
- © 2019 Published by Elsevier Ltd on behalf of Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.159 Membrane Channels & Receptors
- 1.159.576 Adenosine Signaling
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science