Journal article
Cat odor exposure induces distinct changes in the exploratory behavior and Wfs1 gene expression in C57Bl/6 and 129Sv mice
Neuroscience Letters, Vol.426(2), pp.87-90
2007
Abstract
129Sv and C57Bl/6 (Bl6) strains are two most widely used inbred mice strains for generation of transgenic animals. The present study confirms the existence of substantial differences in the behavior of these two mice strains. The exploratory behavior of Bl6 mice in a novel environment was significantly higher compared to 129Sv mice. The exposure of mice to cat odor-induced an anxiety-like state in Bl6, but not in 129Sv mice. The levels of Wfs1 gene expression did not differ in the prefrontal cortex, mesolimbic area and temporal lobe of experimentally naive Bl6 and 129Sv mice. However, after cat odor exposure the expression of Wfs1 gene was significantly lower in the mesolimbic area and temporal lobe of Bl6 mice compared to 129Sv strain. Dynamics of Wfs1 gene expression and exploratory behavior suggest that the down-regulation of Wfs1 gene in Bl6 mice might be related to the increased anxiety. Further studies are needed to test the robustness and possible causal relationship of this finding.
Details
- Title
- Cat odor exposure induces distinct changes in the exploratory behavior and Wfs1 gene expression in C57Bl/6 and 129Sv mice
- Authors/Creators
- S. Raud (Author/Creator) - University of TartuS. Sütt (Author/Creator) - University of TartuM. Plaas (Author/Creator) - University of TartuH. Luuk (Author/Creator) - University of TartuJ. Innos (Author/Creator) - University of TartuM-A Philips (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of Tartu
- Publication Details
- Neuroscience Letters, Vol.426(2), pp.87-90
- Publisher
- Elsevier
- Identifiers
- 991005544929907891
- Copyright
- © 2007 Elsevier Ireland Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis
- 1.25.1406 Unfolded Protein Response
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior