Journal article
Cell-Mediated cytotoxicity to muscle in polymyositis
New England Journal of Medicine, Vol.288(9), pp.434-438
1973
Abstract
Immunologic injury to cultures of skeletal muscle was studied in patients with polymyositis by means of a 51Cr release method that allows quantitation of myocyte injury. Lymphocyte-mediated myotoxicity was elevated in a group of nine patients with active disease (p<0.001) but was normal in four patients with inactive disease. There was no evidence of antibody-mediated cytotoxicity.
Lymphocyte-mediated myotoxicity in the active group was analyzed in relation to treatment and immunosuppression in six of the nine patients. Seven tests on patients on immunosuppressive therapy gave normal lymphocyte-mediated myotoxicity values of 1.0 ± 4.2 per cent (mean ± S.D.), whereas eight tests on patients who were on less than immunosuppressive therapy yielded elevated lymphocyte-mediated myotoxicity: 24.4 ± 10.6 per cent, with a significant difference between these two groups (p < 0.001). These data suggest that the pathogenesis of polymyositis involves a cell-mediated immunologic reaction directed against skeletal muscle, and that immunosuppressive therapy may exert its clinical effect by decreasing lymphocyte myotoxicity.
Details
- Title
- Cell-Mediated cytotoxicity to muscle in polymyositis
- Authors/Creators
- R.L. Dawkins (Author/Creator)F.L. Mastaglia (Author/Creator)
- Publication Details
- New England Journal of Medicine, Vol.288(9), pp.434-438
- Publisher
- Massachusetts Medical Society
- Identifiers
- 991005545007507891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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