Journal article
Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice
Journal of Autoimmunity, Vol.32(2), pp.85-93
2009
Abstract
This study was designed to examine immunopathology of diabetic nephropathy in non-obese diabetic (NOD) mice and to investigate the involvement of cellular and humoral immunity at various time points after diabetes onset. We found that the glomeruli of diabetic NOD mice were infiltrated with T and B cells, as well as CD11c+ dendritic cells, which had close contact with CD4+ and CD8+ T cells in the infiltrates. We also found that IgG deposits in the glomeruli of diabetic NOD mice were accompanied by the presence of complement C3. Moreover, the serum from diabetic mice contained autoantibodies directed towards components of the glomeruli and these antibodies were not present in non-diabetic NOD mice. The immune changes in the kidney occurred together with increasing kidney weight and urinary albumin excretion along with duration of diabetes. We provide evidence that infiltrating lymphocytes and anti-kidney autoantibodies may be involved in diabetic nephropathy in autoimmune diabetes in the NOD mouse. Understanding the role that the immune system plays in the pathogenesis of diabetic nephropathy could lead to identification of new strategies and/or additional therapeutic targets for prevention and treatment of diabetic nephropathy.
Details
- Title
- Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice
- Authors/Creators
- X. Xiao (Author/Creator) - Yale UniversityB. Ma (Author/Creator) - NYU Langone HealthB. Dong (Author/Creator) - Yale UniversityP. Zhao (Author/Creator) - Shandong Provincial HospitalN. Tai (Author/Creator) - Yale UniversityL. Chen (Author/Creator) - Qilu Hospital of Shandong UniversityF. Susan Wong (Author/Creator)L. Wen (Author/Creator) - Yale University
- Publication Details
- Journal of Autoimmunity, Vol.32(2), pp.85-93
- Publisher
- Elsevier
- Identifiers
- 991005546331707891
- Copyright
- © 2009 Elsevier Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.55 Urology & Nephrology - General
- 1.55.352 Chronic Kidney Disease
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology