Journal article
Cerebral amyloid-β accumulation and deposition following traumatic brain injury—A narrative review and meta-analysis of animal studies
Neuroscience & Biobehavioral Reviews, Vol.64, pp.215-228
2016
Abstract
Traumatic brain injury (TBI) increases the risk of neurodegenerative disorders many years post-injury. However, molecular mechanisms underlying the relationship between TBI and neurodegenerative diseases, such as Alzheimer’s disease (AD), remain to be elucidated. Nevertheless, previous studies have demonstrated a link between TBI and increased amyloid-β (Aβ), a protein involved in AD pathogenesis. Here, we review animal studies that measured Aβ levels following TBI. In addition, from a pool of initially identified 1209 published papers, we examined data from 19 eligible animal model studies using a meta-analytic approach. We found an acute increase in cerebral Aβ levels ranging from 24 h to one month following TBI (overall log OR = 2.97 ± 0.40, p < 0.001). These findings may contribute to further understanding the relationship between TBI and future dementia risk. The methodological inconsistencies of the studies discussed in this review suggest the need for improved and more standardised data collection and study design, in order to properly elucidate the role of TBI in the expression and accumulation of Aβ.
Details
- Title
- Cerebral amyloid-β accumulation and deposition following traumatic brain injury—A narrative review and meta-analysis of animal studies
- Authors/Creators
- S.M. Bird (Author/Creator) - The University of Western AustraliaH.R. Sohrabi (Author/Creator) - The University of Western AustraliaT.A. Sutton (Author/Creator) - The University of Western AustraliaM. Weinborn (Author/Creator) - Hollywood Private HospitalS.R. Rainey-Smith (Author/Creator)B. Brown (Author/Creator) - Hollywood Private HospitalL. Patterson (Author/Creator) - Hollywood Private HospitalK. Taddei (Author/Creator) - Hollywood Private HospitalV. Gupta (Author/Creator) - Hollywood Private HospitalM. Carruthers (Author/Creator) - Edith Cowan UniversityN. Lenzo (Author/Creator) - Oceanic Medical Imaging, Hollywood Medical Centre, 85 Monash Avenue, Nedlands, 6009 WA, Australia.N. Knuckey (Author/Creator) - The University of Western AustraliaR.S. Bucks (Author/Creator) - The University of Western AustraliaG. Verdile (Author/Creator) - The University of Western AustraliaR.N. Martins (Author/Creator) - Edith Cowan University
- Publication Details
- Neuroscience & Biobehavioral Reviews, Vol.64, pp.215-228
- Publisher
- Elsevier
- Identifiers
- 991005541517807891
- Copyright
- © 2016 Elsevier Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.134 Trauma & Emergency Surgery
- 1.134.286 Traumatic Brain Injury
- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- ESI research areas
- Neuroscience & Behavior