Cerebral palsy following term newborn encephalopathy: a population-based study

Nadia Badawi; Janine F Felix; Jennifer J Kurinczuk; Glenys Dixon; Linda Watson; John M Keogh; Jane Valentine; Fiona J Stanley

doi:10.1111/j.1469-8749.2005.tb01139.x

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Cerebral palsy following term newborn encephalopathy: a population-based study

Journal article

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Cerebral palsy following term newborn encephalopathy: a population-based study

Nadia Badawi, Janine F Felix, Jennifer J Kurinczuk, Glenys Dixon, Linda Watson, John M Keogh, Jane Valentine and Fiona J Stanley

Developmental medicine and child neurology, Vol.47(5), pp.293-298

2005

DOI: https://doi.org/10.1111/j.1469-8749.2005.tb01139.x

PMID: 15892370

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Abstract

Cerebral palsy (CP) can occur in term infants with or without preceding newborn encephalopathy. We compared the type and severity of CP and associated disability in these two groups. Participants from a population-based case-control study of term newborn encephalopathy were followed up for 6 years and linked to the Western Australian Cerebral Palsy Register. The remaining term infants with CP for the same period were also identified from the Cerebral Palsy Register. 13% of neonatal survivors of term newborn encephalopathy had CP, a rate of 116 per 1000 term live births. Overall, 24% of term infants with CP followed newborn encephalopathy. CP following newborn encephalopathy was more likely to: affect males (72% vs 56%); be severe (47% vs 25%); and be of spastic quadriplegia or dyskinetic types. Cognitive impairment was more common (75% vs 43%) and severe (41% vs 16%), as was epilepsy (53% vs 29%) in survivors of encephalopathy. These children were also more likely to: be non-verbal (47% vs 22%); have a severe composite disability score (47% vs 26%); and die between time of diagnosis of CP and age 6 years (5-year cumulative mortality 19% vs 5%). Children born at term who develop CP following newborn encephalopathy have a poorer prognosis than those with CP who were not encephalopathic in the first week of life.

Details

Title: Cerebral palsy following term newborn encephalopathy: a population-based study
Authors/Creators: Nadia Badawi - Children's Hospital at Westmead
Janine F Felix - Erasmus MC - Sophia Children’s Hospital
Jennifer J Kurinczuk - University of Oxford
Glenys Dixon - University of Oxford
Linda Watson - The Kids Research Institute Australia
John M Keogh - The University of Sydney
Jane Valentine - Princess Margaret Hospital for Children
Fiona J Stanley - The Kids Research Institute Australia
Publication Details: Developmental medicine and child neurology, Vol.47(5), pp.293-298
Publisher: Cambridge University Press
Number of pages: 6
Identifiers: 991005571150307891
Murdoch Affiliation: Ngangk Yira Institute for Change
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.72 Obstetrics & Gynecology; 1.72.922 Neonatal Hypoxia Effects
Web Of Science research areas: Clinical Neurology; Pediatrics
ESI research areas: Neuroscience & Behavior