Journal article
Changes in circulating microRNAs levels with exercise modality
Journal of Applied Physiology, Vol.115(9), pp.1237-1244
2013
Abstract
Here, we studied muscle-specific and muscle-related miRNAs in plasma of exercising humans. Our aim was to determine whether they are affected by eccentric and/or concentric exercise modes and could be biomarkers of muscle injuries or possible signaling molecules. On two separate days, nine healthy subjects randomly performed two 30-min walking exercises, one downhill (high eccentric component) and one uphill (high concentric component). Perceived exertion and heart rate were higher during the uphill exercise, while subjective pain and ankle plantar flexor strength losses within the first 48-h were higher following the downhill exercise. Both exercises increased serum creatine kinase and myoglobin with no significant differences between conditions. Plasma levels of circulating miRNAs assessed before, immediately after, and at 2-, 6-, 24-, 48-, and 72-h recovery showed that 1) hsa-mir-1, 133a, 133b, and 208b were not affected by concentric exercise but significantly increased during early recovery of eccentric exercise (2 to 6 h); 2) hsa-mir-181b and 214 significantly and transiently increased immediately after the uphill, but not downhill, exercise. The muscle-specific hsa-mir-206 was not reliably quantified and cardiac-specific hsa-mir-208a remained undetectable. In conclusion, changes in circulating miRNAs were dependent on the exercise mode. Circulating muscle-specific miRNAs primarily responded to a downhill exercise (high eccentric component) and could potentially be alternative biomarkers of muscle damage. Two muscle-related miRNAs primarily responded to an uphill exercise (high exercise intensity), suggesting they could be markers or mediators of physiological adaptations.
Details
- Title
- Changes in circulating microRNAs levels with exercise modality
- Authors/Creators
- S. Banzet (Author/Creator) - Institut de Recherche Biomédicale des Armées, Armed Forces Biomedical Research Institute, Brétigny sur Orge, France;M. Chennaoui (Author/Creator) - Institut de Recherche Biomédicale des ArméesO. Girard (Author/Creator) - Qatar Orthopaedic and Sports Medicine HospitalS. Racinais (Author/Creator) - Qatar Orthopaedic and Sports Medicine HospitalC. Drogou (Author/Creator) - Institut de Recherche Biomédicale des ArméesH. Chalabi (Author/Creator) - Qatar Orthopaedic and Sports Medicine HospitalN. Koulmann (Author/Creator) - HIA du Val-de-Grâce à Paris
- Publication Details
- Journal of Applied Physiology, Vol.115(9), pp.1237-1244
- Publisher
- American Physiological Society
- Identifiers
- 991005540229507891
- Copyright
- © 2013 the American Physiological Society
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
29 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.196 Micro & Long Noncoding RNA
- 1.196.68 MicroRNA in Cancer
- Web Of Science research areas
- Physiology
- Sport Sciences
- ESI research areas
- Biology & Biochemistry