Changes in corticomotor excitation and inhibition during prolonged submaximal muscle contractions

P. Sacco; G.W. Thickbroom; M.L. Thompson; F.L. Mastaglia

doi:10.1002/(SICI)1097-4598(199709)20:9<1158::AID-MUS11>3.0.CO;2-P

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Changes in corticomotor excitation and inhibition during prolonged submaximal muscle contractions

Journal article

Peer reviewed

Changes in corticomotor excitation and inhibition during prolonged submaximal muscle contractions

P. Sacco, G.W. Thickbroom, M.L. Thompson and F.L. Mastaglia

Muscle & Nerve, Vol.20(9), pp.1158-1166

1997

DOI: https://doi.org/10.1002/(SICI)1097-4598(199709)20:9<1158::AID-MUS11>3.0.CO;2-P

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Abstract

Changes in motor evoked potential (MEP) amplitude, post-MEP silent period duration, and interpolated twitch torque were measured using transcranial magnetic (TMS) and electrical (TES) stimulation during a 20% maximum voluntary contraction of the elbow flexors sustained to exhaustion. TMS- and TES-induced MEP amplitude increased progressively over the contraction period up until the point of exhaustion. The TMS-induced silent period was prolonged only during the second half of the contraction period, the time course being different from that of the MEP responses, whereas the TES-induced silent period did not change. The findings indicate that corticomotor excitability increases during a sustained submaximal voluntary contraction and that, as fatigue develops, there is a progressive buildup of intracortical inhibition. This may represent a mechanism whereby corticomotor output is maintained at an appropriate level to preserve optimal motor unit firing frequencies during a fatiguing contraction.

Details

Title: Changes in corticomotor excitation and inhibition during prolonged submaximal muscle contractions
Authors/Creators: P. Sacco (Author/Creator) - Edith Cowan University
G.W. Thickbroom (Author/Creator) - Queen Elizabeth II Medical Centre
M.L. Thompson (Author/Creator) - Queen Elizabeth II Medical Centre
F.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical Centre
Publication Details: Muscle & Nerve, Vol.20(9), pp.1158-1166
Publisher: John Wiley and Sons Inc.
Identifiers: 991005540219907891
Copyright: © 1997 John Wiley & Sons, Inc.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.82 Gait & Posture; 1.82.811 Transcranial Magnetic Stimulation
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior