Journal article
Changes in serum neurofilament light chain levels following narrowband ultraviolet B phototherapy in clinically isolated syndrome
Brain and Behavior, Vol.12(2), Art. e2494
2022
Abstract
Objective
To determine whether serum neurofilament light chain (sNfL) levels are suppressed in patients with the clinically isolated syndrome (CIS) following narrowband ultraviolet B phototherapy (UVB-PT).
Methods
sNfL levels were measured using a sensitive single-molecule array assay at baseline and up to 12 months in 17 patients with CIS, 10 of whom received UVB-PT, and were compared with healthy control (HC) and early relapsing remitting multiple sclerosis (RRMS) group. sNfL levels were correlated with magnetic resonance imaging total lesion volume (LV) determined using icobrain version 4.4.1 and with clinical outcomes.
Results
Baseline median sNfL levels were significantly higher in the CIS (20.6 pg/mL, interquartile range [IQR] 13.7–161.4) and RRMS groups (36.6 pg/ml [IQR] 16.2–212.2) than in HC (10.7 pg/ml [IQR] 4.9–21.5) (p = .012 and p = .0002, respectively), and were strongly correlated with T2 and T1 LV at 12 months (r = .800; p = .014 and r = .833; p = .008, respectively) in the CIS group. Analysis of changes in sNfL levels over time in the CIS group showed a significant cumulative suppressive effect of UVB-PT in the first 3 months (UVB-PT −10.6% vs non-UVB-PT +58.3%; p = .04) following which the levels in the two groups converged and continued to fall.
Conclusions
Our findings provide the basis for further studies to determine the utility of sNfL levels as a marker of neuro-axonal damage in CIS and early MS and for assessing the efficacy of new therapeutic interventions such as UVB-PT.
Details
- Title
- Changes in serum neurofilament light chain levels following narrowband ultraviolet B phototherapy in clinically isolated syndrome
- Authors/Creators
- M.J. Fabis‐Pedrini (Author/Creator)J. Kuhle (Author/Creator) - University of BaselK.M.A. Roberts (Author/Creator) - Perron Institute for Neurological and Translational ScienceS. Trend (Author/Creator) - The Kids Research Institute AustraliaA.P. Jones (Author/Creator) - The Kids Research Institute AustraliaA. Maceski (Author/Creator) - University of BaselW.M. Carroll (Author/Creator) - Perron Institute for Neurological and Translational ScienceR.M. Lucas (Author/Creator) - The University of Western AustraliaF.L. Mastaglia (Author/Creator) - Murdoch UniversityP.H. Hart (Author/Creator) - The Kids Research Institute AustraliaA.G. Kermode (Author/Creator) - Murdoch University
- Publication Details
- Brain and Behavior, Vol.12(2), Art. e2494
- Publisher
- Wiley Periodicals, Inc.
- Identifiers
- 991005540304007891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- ESI research areas
- Neuroscience & Behavior