Journal article
Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
Genetics Selection Evolution, Vol.43(1), Art. 13
2011
Abstract
Background
Leg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs.
Methods
Three hundred and ten F2 pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software.
Results
Eleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level.
Conclusions
Our results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs.
Details
- Title
- Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
- Authors/Creators
- W. Laenoi (Author/Creator) - University of BonnM.J. Uddin (Author/Creator) - University of BonnM.U. Çınar (Author/Creator)C. Große-Brinkhaus (Author/Creator) - University of BonnD. Tesfaye (Author/Creator) - University of BonnE. Jonas (Author/Creator) - University of BonnA.M. Scholz (Author/Creator) - Ludwig-Maximilians-Universität MünchenE. Tholen (Author/Creator) - University of BonnC. Looft (Author/Creator) - University of BonnK. Wimmers (Author/Creator) - Research Institute for Farm Animal Biology (FBN)C. Phatsara (Author/Creator) - Chiang Mai UniversityH. Juengst (Author/Creator) - University of BonnH. Sauerwein (Author/Creator) - University of BonnM. Mielenz (Author/Creator) - University of BonnK. Schellander (Author/Creator) - University of Bonn
- Publication Details
- Genetics Selection Evolution, Vol.43(1), Art. 13
- Publisher
- BMC part of Springer Nature
- Identifiers
- 991005541628107891
- Copyright
- © 2011 Laenoi et al
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.51 Dairy & Animal Sciences
- 3.51.799 Farm Animal Welfare
- Web Of Science research areas
- Agriculture, Dairy & Animal Science
- Genetics & Heredity
- ESI research areas
- Agricultural Sciences