Journal article
Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China
Journal of Virology, Vol.76(1), pp.118-126
2002
Abstract
The H5N1 influenza virus, which killed humans and poultry in 1997, was a reassortant that possibly arose in one type of domestic poultry present in the live-poultry markets of Hong Kong. Given that all the precursors of H5N1/97 are still circulating in poultry in southern China, the reassortment event that generated H5N1 could be repeated. Because A/goose/Guangdong/1/96-like (H5N1; Go/Gd) viruses are the proposed donors of the hemagglutinin gene of the H5N1 virus, we investigated the continued circulation, host range, and transmissibility of Go/Gd-like viruses in poultry. The Go/Gd-like viruses caused weight loss and death in some mice inoculated with high virus doses. Transmission of Go/Gd-like H5N1 viruses to geese by contact with infected geese resulted in infection of all birds but limited signs of overt disease. In contrast, oral inoculation with high doses of Go/Gd-like viruses resulted in the deaths of up to 50% of infected geese. Transmission from infected geese to chickens occurred only by fecal contact, whereas transmission to quail occurred by either aerosol or fecal spread. This difference is probably explained by the higher susceptibility of quail to Go/Gd-like virus. The high degree of susceptibility of quail to Go/Gd (H5N1)-like viruses and the continued circulation of H6N1 and H9N2 viruses in quail support the hypothesis that quail were the host of origin of the H5N1/97 virus. The ease of transmission of Go/Gd (H5N1)-like viruses to land-based birds, especially quail, supports the wisdom of separating aquatic and land-based poultry in the markets in Hong Kong and the need for continued surveillance in the field and live-bird markets in which different types of poultry are in contact with one another.
Details
- Title
- Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China
- Authors/Creators
- R.G. Webster (Author/Creator)Y. Guan (Author/Creator)M. Peiris (Author/Creator)D. Walker (Author/Creator)S. Krauss (Author/Creator)N.N. Zhou (Author/Creator)E.A. Govorkova (Author/Creator)T.M. Ellis (Author/Creator)K.C. Dyrting (Author/Creator)T. Sit (Author/Creator)D.R. Perez (Author/Creator)K.F. Shortridge (Author/Creator)
- Publication Details
- Journal of Virology, Vol.76(1), pp.118-126
- Publisher
- American Society for Microbiology
- Identifiers
- 991005540521007891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
36 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.104 Virology - General
- 1.104.126 Influenza
- Web Of Science research areas
- Virology
- ESI research areas
- Microbiology