Journal article
Characterization of a novel staphylococcal cassette chromosome composite island from community-associated MRSA isolated in aged care facilities in Western Australia
Journal of Antimicrobial Chemotherapy, Vol.71(12), pp.3372-3375
2016
Abstract
Background: In Western Australia (WA), clonal complex 5, ST835, community-associated (CA) MRSA is isolated almost exclusively from aged care facilities. In WA four different staphylococcal cassette chromosome (SCC) mec (SCCmec) elements have been identified in this ST, indicating high genetic activity in the SCCmec region.
Objectives: To investigate the SCC region of ST835 CA-MRSAWA MRSA-40 and determine the distribution of an SCCsorbitol element found within the region.
Results: The SCC region contained a composite island, SCCmec(WA MRSA-40)-CI, that was composed of three elements, Psi SCCpls, SCCsorbitol and SCCmecV(T) (5C2&5). This is the first time that a sorbitol operon has been reported in an SCC element.
Conclusions: Generation of SCCmecWA MRSA-40-CI has involved multiple genetic events and recombination with CoNS has occurred during evolution of the SCC elements. While Staphylococcus aureus is renowned for its ability to utilize mobile genetic elements to disseminate antimicrobial resistance, the SCC region of WA MRSA-40 shows that this clone has also utilized SCC elements to acquire extra virulence and possibly adapt to a niche environment.
Details
- Title
- Characterization of a novel staphylococcal cassette chromosome composite island from community-associated MRSA isolated in aged care facilities in Western Australia
- Authors/Creators
- L.K. Wilson (Author/Creator)G.W. Coombs (Author/Creator)K. Christiansen (Author/Creator)W.B. Grubb (Author/Creator)F.G. O'Brien (Author/Creator)
- Publication Details
- Journal of Antimicrobial Chemotherapy, Vol.71(12), pp.3372-3375
- Publisher
- Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy
- Identifiers
- 991005543217307891
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Infectious Diseases
- Microbiology
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology