Journal article
Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans
Journal of General Virology, Vol.91(3), pp.653-658
2010
Abstract
Serological screening of sera from orang-utans demonstrated a high percentage of sera that cross-reacted with antigens of the polyomavirus (PyV) simian virus 40. Analysis of archival DNA samples from 71 Bornean and eight Sumatran orang-utans with a broad-spectrum PCR assay resulted in the detection of PyV infections in 11 animals from both species. Sequence analysis of the amplicons revealed considerable differences between the PyVs from Bornean and Sumatran orang-utans. The genome from two PyVs, one from each species, was therefore amplified and sequenced. Both viral genomes revealed a characteristic PyV architecture, but lacked an obvious agnogene. Neighbour-joining analysis positioned the viruses in a large cluster together with viruses from bats, bovines, rodents and several primate PyVs from chimpanzees, African green monkeys, squirrel monkeys and the human Merkel cell PyV.
Details
- Title
- Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans
- Authors/Creators
- M.J. Groenewoud (Author/Creator) - Biomedical Primate Research CentreZ. Fagrouch (Author/Creator) - Biomedical Primate Research CentreS. van Gessel (Author/Creator) - Biomedical Primate Research CentreH. Niphuis (Author/Creator) - Biomedical Primate Research CentreA. Bulavaite (Author/Creator) - Czech Academy of Sciences, Institute of BiotechnologyK.S. Warren (Author/Creator) - Murdoch UniversityJ. L. Heeney (Author/Creator) - Biomedical Primate Research CentreE. J. Verschoor (Author/Creator) - Biomedical Primate Research Centre
- Publication Details
- Journal of General Virology, Vol.91(3), pp.653-658
- Publisher
- Society for General Microbiology
- Identifiers
- 991005542621007891
- Copyright
- 2010 SGM
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.161 Virology - Identification & Sequencing
- 1.161.1385 Polyomavirus Oncogenesis
- Web Of Science research areas
- Biotechnology & Applied Microbiology
- Virology
- ESI research areas
- Microbiology