Childhood Hospitalisation with Infection and Cardiovascular Disease in Early-Mid Adulthood: A Longitudinal Population-Based Study

David P. Burgner; Matthew N. Cooper; Hannah C. Moore; Fiona J. Stanley; Peter L. Thompson; Nicholas H. de Klerk; Kim W. Carter

doi:10.1371/journal.pone.0125342

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Childhood Hospitalisation with Infection and Cardiovascular Disease in Early-Mid Adulthood: A Longitudinal Population-Based Study

Journal article

Open access

Peer reviewed

Childhood Hospitalisation with Infection and Cardiovascular Disease in Early-Mid Adulthood: A Longitudinal Population-Based Study

David P. Burgner, Matthew N. Cooper, Hannah C. Moore, Fiona J. Stanley, Peter L. Thompson, Nicholas H. de Klerk and Kim W. Carter

PloS one, Vol.10(5), e0125342

2015

DOI: https://doi.org/10.1371/journal.pone.0125342

PMCID: PMC4418819

PMID: 25938548

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Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Background Pathogen-specific and overall infection burden may contribute to atherosclerosis and cardiovascular disease (CVD), but the effect of infection severity and timing is unknown. We investigated whether childhood infection-related hospitalisation (IRH, a marker of severity) was associated with subsequent adult CVD hospitalisation. Methods Using longitudinal population-based statutorily-collected administrative health data from Western Australia (1970-2009), we identified adults hospitalised with CVD (ischaemic heart disease, ischaemic stroke, and peripheral vascular disease) and matched them (10:1) to population controls. We used Cox regression to assess relationships between number and type of childhood IRH and adulthood CVD hospitalisation, adjusting for sex, age, Indigenous status, socioeconomic status, and birth weight. Results 631 subjects with CVD-related hospitalisation in adulthood (>= 18 years) were matched with 6310 controls. One or more childhood (< 18 years) IRH was predictive of adult CVD-related hospitalisation (adjusted hazard ratio, 1.3; 95% CI 1.1-1.6; P < 0.001). The association showed a dose-response; >= 3 childhood IRH was associated with a 2.2 times increased risk of CVD-related hospitalisation in adulthood (adjusted hazard ratio, 2.2; 95% CI 1.7-2.9; P < 0.001). The association was observed across all clinical diagnostic groups of infection (upper respiratory tract infection, lower respiratory tract infection, infectious gastroenteritis, urinary tract infection, skin and soft tissue infection, and other viral infection), and individually with CVD diagnostic categories (ischaemic heart disease, ischaemic stroke and peripheral vascular disease). Conclusions Severe childhood infection is associated with CVD hospitalisations in adulthood in a dose-dependent manner, independent of population-level risk factors.

Details

Title: Childhood Hospitalisation with Infection and Cardiovascular Disease in Early-Mid Adulthood: A Longitudinal Population-Based Study
Authors/Creators: David P. Burgner - The University of Western Australia
Matthew N. Cooper - Univ Western Australia, Telethon Kids Inst, Div Populat Sci, Subiaco, WA, Australia
Hannah C. Moore - The Kids Research Institute Australia
Fiona J. Stanley - The University of Western Australia
Peter L. Thompson - Sir Charles Gairdner Hospital
Nicholas H. de Klerk - The Kids Research Institute Australia
Kim W. Carter - The Kids Research Institute Australia
Publication Details: PloS one, Vol.10(5), e0125342
Publisher: Public Library of Science
Number of pages: 12
Grant note: Victorian Government's Operational Infrastructure Support Program APP1064629 / National Health and Medical Research Council, Australia; National Health and Medical Research Council (NHMRC) of Australia 100026 / National Heart Foundation, Australia; National Heart Foundation of Australia National Health and Medical Research Council, Australia; National Health and Medical Research Council (NHMRC) of Australia University of Western Australia Research Development Award McCusker Charitable Foundation Bioinformatics Centre
Identifiers: 991005570073007891
Murdoch Affiliation: Ngangk Yira Institute for Change
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.248 Sexually Transmitted Infections; 1.248.655 Chlamydia Infections
Web Of Science research areas: Multidisciplinary Sciences
ESI research areas: Clinical Medicine