Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes

Nathan G Lawler; Lael M Yonker; Samantha Lodge; Philipp Nitschke; Maureen M Leonard; Nicola Gray; Luke Whiley; Reika Masuda; Elaine Holmes; Julien Wist; Alessio Fasano; Jeremy K Nicholson

doi:10.1021/acs.jproteome.5c00062

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Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes

Journal article

Open access

Peer reviewed

Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes

Nathan G Lawler, Lael M Yonker, Samantha Lodge, Philipp Nitschke, Maureen M Leonard, Nicola Gray, Luke Whiley, Reika Masuda, Elaine Holmes, Julien Wist, …

Journal of proteome research, Vol.24(7), pp.3470-3483

2025

DOI: https://doi.org/10.1021/acs.jproteome.5c00062

PMID: 40490306

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Abstract

SARS-CoV-2

lipids

hyper-inflammation

inflammation

phenoconversion

nuclear magnetic resonance spectroscopy

mass spectrometry

lipoproteins

SARS-CoV-2 infections in children lead to symptoms from mild respiratory illness to severe postacute sequelae of COVID-19, including multisystem inflammatory syndrome in Children (MIS-C). We conducted a metabolic profiling of 147 children's serum samples, including acute COVID-19 patients, MIS-C patients, and healthy controls. Using nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry, we measured 1101 metabolites. The results revealed distinct metabolic profiles in acute COVID-19 and MIS-C patients, with significant alterations in lipid classes. Both conditions exhibited an elevated Apo-B100/Apo-A1 ratio and increased serum inflammatory markers. MIS-C patients showed unique disruptions, including increased triglycerides and altered lipoprotein composition. Despite milder clinical respiratory symptoms, children's metabolic disturbances mirrored those seen in severe adult COVID-19 patients, indicating a shared inflammatory response to SARS-CoV-2. This suggests potential long-term health impacts, underscoring the need for continued research into the metabolic consequences of COVID-19 in children.

Details

Title: Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes
Authors/Creators: Nathan G Lawler - Murdoch University, Health Futures Institute
Lael M Yonker - Harvard Medical School, Boston, Massachusetts 02115, United States
Samantha Lodge - Murdoch University, Centre for Computational and Systems Medicine
Philipp Nitschke - Murdoch University
Maureen M Leonard - Massachusetts General Hospital
Nicola Gray - Murdoch University, Centre for Computational and Systems Medicine
Luke Whiley - Murdoch University, Centre for Computational and Systems Medicine
Reika Masuda - Murdoch University
Elaine Holmes - Murdoch University, Centre for Computational and Systems Medicine
Julien Wist - Murdoch University, Centre for Computational and Systems Medicine
Alessio Fasano - Massachusetts General Hospital
Jeremy K Nicholson - Murdoch University, Health Futures Institute
Publication Details: Journal of proteome research, Vol.24(7), pp.3470-3483
Publisher: ACS Publications
Number of pages: 14
Identifiers: 991005786084007891
Murdoch Affiliation: Australian National Phenome Centre; Health Futures Institute; Centre for Computational and Systems Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.211 Mass Spectrometry; 2.211.990 Metabolomics
Web Of Science research areas: Biochemical Research Methods
ESI research areas: Biology & Biochemistry