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CC BY-NC-ND V4.0, Open Access
Journal article
Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes
Journal of proteome research, Vol.24(7), pp.3470-3483
2025
PMID: 40490306
Abstract
SARS-CoV-2 infections in children lead to symptoms from mild respiratory illness to severe postacute sequelae of COVID-19, including multisystem inflammatory syndrome in Children (MIS-C). We conducted a metabolic profiling of 147 children's serum samples, including acute COVID-19 patients, MIS-C patients, and healthy controls. Using nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry, we measured 1101 metabolites. The results revealed distinct metabolic profiles in acute COVID-19 and MIS-C patients, with significant alterations in lipid classes. Both conditions exhibited an elevated Apo-B100/Apo-A1 ratio and increased serum inflammatory markers. MIS-C patients showed unique disruptions, including increased triglycerides and altered lipoprotein composition. Despite milder clinical respiratory symptoms, children's metabolic disturbances mirrored those seen in severe adult COVID-19 patients, indicating a shared inflammatory response to SARS-CoV-2. This suggests potential long-term health impacts, underscoring the need for continued research into the metabolic consequences of COVID-19 in children.
Details
- Title
- Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes
- Authors/Creators
- Nathan G Lawler - Murdoch University, Health Futures InstituteLael M Yonker - Harvard Medical School, Boston, Massachusetts 02115, United StatesSamantha Lodge - Murdoch University, Centre for Computational and Systems MedicinePhilipp Nitschke - Murdoch UniversityMaureen M Leonard - Massachusetts General HospitalNicola Gray - Murdoch University, Centre for Computational and Systems MedicineLuke Whiley - Murdoch University, Centre for Computational and Systems MedicineReika Masuda - Murdoch UniversityElaine Holmes - Murdoch University, Centre for Computational and Systems MedicineJulien Wist - Murdoch University, Centre for Computational and Systems MedicineAlessio Fasano - Massachusetts General HospitalJeremy K Nicholson - Murdoch University, Health Futures Institute
- Publication Details
- Journal of proteome research, Vol.24(7), pp.3470-3483
- Publisher
- ACS Publications
- Number of pages
- 14
- Identifiers
- 991005786084007891
- Copyright
- © 2025 The Authors.
- Murdoch Affiliation
- Australian National Phenome Centre; Health Futures Institute; Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.211 Mass Spectrometry
- 2.211.990 Metabolomics
- Web Of Science research areas
- Biochemical Research Methods
- ESI research areas
- Biology & Biochemistry