Choline chloride in the treatment of cerebellar and spinocerebellar ataxia

I.R. Livingstone; F.L. Mastaglia; R.J.T. Pennington; C. Skilbeck

doi:10.1016/0022-510X(81)90162-3

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Choline chloride in the treatment of cerebellar and spinocerebellar ataxia

Journal article

Peer reviewed

Choline chloride in the treatment of cerebellar and spinocerebellar ataxia

I.R. Livingstone, F.L. Mastaglia, R.J.T. Pennington and C. Skilbeck

Journal of the Neurological Sciences, Vol.50(2), pp.161-174

1981

DOI: https://doi.org/10.1016/0022-510X(81)90162-3

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Abstract

The use of orally administered choline chloride in the treatment of cerebellar and spinocerebellar ataxia was investigated by a short-term double-blind crossover trial in 20 patients with ataxia. These patients, who included 7 with Friedreich's ataxia, 7 with mixed spinocerebellar ataxia and 6 with primary cerebellar degeneration received placebo and 6 g/day or 12 g/day of choline with crossover at 6 weeks. Serum choline levels were measured 1 h after the first daily dose. Mild but significant improvement in upper limb co-ordination was noted in 3 patients with Friedreich's ataxia, 3 with mixed ataxia and 4 patients with primary cerebellar degeneration. Improvement in gait and lower limb co-ordination was observed in only 2 patients (one with cerebellar ataxia and 1 with mixed ataxia). There was no correlation between serum choline levels and clinical response to choline. Choline chloride produces a mild but functionally significant improvement in motor co-ordination in some patients with cerebellar and spinocerebellar ataxia.

Details

Title: Choline chloride in the treatment of cerebellar and spinocerebellar ataxia
Authors/Creators: I.R. Livingstone (Author/Creator) - Muscular Dystrophy Group Research laboratories, Regional Neurological Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE46BE Great Britain
F.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical Centre
R.J.T. Pennington (Author/Creator) - Muscular Dystrophy Group Research laboratories, Regional Neurological Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE46BE Great Britain
C. Skilbeck (Author/Creator) - Frenchay Hospital
Publication Details: Journal of the Neurological Sciences, Vol.50(2), pp.161-174
Publisher: Elsevier BV
Identifiers: 991005541665407891
Copyright: © 1981 Elsevier B.V.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.5 Neuroscience; 1.5.949 Cholinergic Systems
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior