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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Cholinergic basal forebrain volumes predict gait decline in Parkinson's disease
Movement Disorders, Vol.36(3), pp.611-621
2021
Abstract
Background
Gait disturbance is an early, disabling feature of Parkinson's disease (PD) that is typically refractory to dopaminergic medication. The cortical cholinergic system, originating in the nucleus basalis of Meynert of the basal forebrain, has been implicated. However, it is not known if degeneration in this region relates to a worsening of disease-specific gait impairment.
Objective
To evaluate associations between sub-regional cholinergic basal forebrain volumes and longitudinal progression of gait impairment in PD.
Methods
99 PD participants and 47 control participants completed gait assessments via an instrumented walkway during 2 minutes of continuous walking, at baseline and for up to 3 years, from which 16 spatiotemporal characteristics were derived. Sub-regional cholinergic basal forebrain volumes were measured at baseline via MRI and a regional map derived from post-mortem histology. Univariate analyses evaluated cross-sectional associations between sub-regional volumes and gait. Linear mixed-effects models assessed whether volumes predicted longitudinal gait changes.
Results
There were no cross-sectional, age-independent relationships between sub-regional volumes and gait. However, nucleus basalis of Meynert volumes predicted longitudinal gait changes unique to PD. Specifically, smaller nucleus basalis of Meynert volume predicted increasing step time variability (P = 0.019) and shortening swing time (P = 0.015); smaller posterior nucleus portions predicted shortening step length (P = 0.007) and increasing step time variability (P = 0.041).
Conclusions
This is the first study to demonstrate that degeneration of the cortical cholinergic system predicts longitudinal progression of gait impairments in PD. Measures of this degeneration may therefore provide a novel biomarker for identifying future mobility loss and falls. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Details
- Title
- Cholinergic basal forebrain volumes predict gait decline in Parkinson's disease
- Authors/Creators
- J. Wilson (Author/Creator) - Newcastle UniversityA.J. Yarnall (Author/Creator) - University of Newcastle AustraliaC.E. Craig (Author/Creator) - Manchester Metropolitan UniversityB. Galna (Author/Creator) - Newcastle UniversityS. Lord (Author/Creator) - Auckland University of TechnologyR. Morris (Author/Creator) - Northumbria UniversityR.A. Lawson (Author/Creator) - University of Newcastle AustraliaL. Alcock (Author/Creator) - Newcastle UniversityG.W. Duncan (Author/Creator) - University of EdinburghT.K. Khoo (Author/Creator) - Griffith UniversityJ.T. O'Brien (Author/Creator) - University of CambridgeD.J. Burn (Author/Creator) - University of Newcastle AustraliaJ.‐P. Taylor (Author/Creator)N.J. Ray (Author/Creator) - Manchester Metropolitan UniversityL. Rochester (Author/Creator) - Newcastle University
- Publication Details
- Movement Disorders, Vol.36(3), pp.611-621
- Publisher
- Wiley Online Library
- Identifiers
- 991005545250707891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.67 Parkinson's Disease
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior