Journal article
Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus
Scientific Reports, Vol.11(1), Art. 10331
2021
Abstract
Chorioamnionitis, inflammation of fetal membranes, is an important cause of preterm birth and a risk factor for the development of adverse neonatal outcomes including sepsis and intestinal pathologies. Intestinal bile acids (BAs) accumulation and hepatic cytokine production are involved in adverse intestinal outcomes. These findings triggered us to study the liver and enterohepatic circulation (EHC) following intra-amniotic (IA) lipopolysaccharide (LPS) exposure. An ovine chorioamnionitis model was used in which circulatory cytokines and outcomes of the liver and EHC of preterm lambs were longitudinally assessed following IA administration of 10 mg LPS at 5, 12 or 24h or 2, 4, 8 or 15d before preterm birth. Hepatic inflammation was observed, characterized by increased hepatic cytokine mRNA levels (5h – 2d post IA LPS exposure) and increased erythropoietic clusters (at 8 and 15 days post IA LPS exposure). Besides, 12h after IA LPS exposure, plasma BA levels were increased, whereas gene expression levels of several hepatic BA transporters were decreased. Initial EHC alterations normalized over time. Concluding, IA LPS exposure induces significant time-dependent changes in the fetal liver and EHC. These chorioamnionitis induced changes have potential postnatal consequences and the duration of IA LPS exposure might be essential herein.
Details
- Title
- Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus
- Authors/Creators
- C. Heymans (Author/Creator) - Maastricht UniversityM. den Dulk (Author/Creator)K. Lenaerts (Author/Creator) - Maastricht UniversityL.R. Heij (Author/Creator) - Maastricht UniversityI.H. de Lange (Author/Creator) - Maastricht UniversityM. Hadfoune (Author/Creator) - Maastricht UniversityC. van Heugten (Author/Creator) - Maastricht UniversityB.W. Kramer (Author/Creator) - Maastricht UniversityA.H. Jobe (Author/Creator) - Cincinnati Children's Hospital Medical CenterM. Saito (Author/Creator) - Tohoku University HospitalM.W. Kemp (Author/Creator) - The University of Western AustraliaT.G.A.M. Wolfs (Author/Creator) - Maastricht UniversityW.G. van Gemert (Author/Creator) - Maastricht University
- Publication Details
- Scientific Reports, Vol.11(1), Art. 10331
- Publisher
- Springer Nature
- Identifiers
- 991005541976707891
- Copyright
- © 2021 Springer Nature Limited
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.72 Obstetrics & Gynecology
- 1.72.924 Preterm Birth Causes
- Web Of Science research areas
- Multidisciplinary Sciences
- ESI research areas
- Clinical Medicine