Chromosome-Contiguous Reference Genome for Spirometra to Underpin Future Discovery Research

Neil D Young; Richard Malik; Alexa Brown; Tao Wang; Amanda Ash; Pasi K Korhonen; Robin B Gasser

doi:10.3390/ijms26136417

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Chromosome-Contiguous Reference Genome for Spirometra to Underpin Future Discovery Research

Journal article

Open access

Peer reviewed

Chromosome-Contiguous Reference Genome for Spirometra to Underpin Future Discovery Research

Neil D Young, Richard Malik, Alexa Brown, Tao Wang, Amanda Ash, Pasi K Korhonen and Robin B Gasser

International journal of molecular sciences, Vol.26(13), 6417

2025

DOI: https://doi.org/10.3390/ijms26136417

PMID: 40650196

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Abstract

Animals

Chromosomes - genetics

Genome, Helminth

Humans

Sparganosis - parasitology

Spirometra - genetics

Sparganosis is a neglected food- and water-borne zoonotic disease caused by members of the tapeworm genus Spirometra. More than 1600 human cases have been reported in the literature, primarily in Korea and China; however, the clinical significance of sparganosis is likely underestimated. The control of this disease is challenging in endemic regions because of the complexity of its lifecycle and the involvement of many animal host species, and treatment of clinical disease in humans and animals with selected drugs (e.g., mebendazole and/or praziquantel), even at elevated doses, is often ineffective, such that novel interventions are needed. It is anticipated that the use of molecular technologies should allow the identification of new intervention targets in crucial biological processes and/or pathways of Spirometra spp. While some draft genomes of Spirometra have been produced, their assemblies are incomplete. Here, we employed an advanced DNA sequencing–informatic approach to assemble and annotate the first high-quality genome of an isolate of Spirometra from Australia, with chromosome-level contiguity and a curated gene set. This improved genome provides a useful resource to support fundamental and applied molecular investigations of Spirometra species and should assist in the design of new tools for the intervention against sparganosis of companion animals (including dogs and cats) and humans.

Details

Title: Chromosome-Contiguous Reference Genome for Spirometra to Underpin Future Discovery Research
Authors/Creators: Neil D Young - The University of Melbourne
Richard Malik - The University of Sydney
Alexa Brown - WAVES Veterinary Hospital, 1/640 Beeliar Drive, Success, Perth, WA 6164, Australia
Tao Wang - The University of Melbourne
Amanda Ash - Murdoch University, Centre for Biosecurity and One Health
Pasi K Korhonen - The University of Melbourne
Robin B Gasser - The University of Melbourne
Publication Details: International journal of molecular sciences, Vol.26(13), 6417
Publisher: MDPI
Number of pages: 17
Identifiers: 991005795471007891
Murdoch Affiliation: Centre for Biosecurity and One Health; School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.163 Parasitology - General; 1.163.1106 Echinococcosis
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
ESI research areas: Chemistry