Chronic neuropsychiatric sequelae of SARS‐CoV‐2: Protocol and methods from the Alzheimer's Association Global Consortium: Protocol and methods from the Alzheimer's Association Global Consortium

G.A. de Erausquin; H. Snyder; T.S. Brugha; S. Seshadri; M. Carrillo; R. Sagar; Y. Huang; C. Newton; C. Tartaglia; C. Teunissen; K. Håkanson; R. Akinyemi; K. Prasad; G. D'Avossa; G. Gonzalez‐Aleman; A. Hosseini; G.D. Vavougios; P. Sachdev; J. Bankart; N.P.O. Mors; R. Lipton; M. Katz; P.T. Fox; M.Z. Katshu; M.S. Iyengar; G. Weinstein; H.R. Sohrabi; R. Jenkins; D.J. Stein; J. Hugon; V. Mavreas; J. Blangero; C. Cruchaga; M. Krishna; O. Wadoo; R. Becerra; I. Zwir; W.T. Longstreth; G. Kroenenberg; P. Edison; E. Mukaetova‐Ladinska; E. Staufenberg; M. Figueredo‐Aguiar; A. Yécora; F. Vaca; H.P. Zamponi; V.L. Re; A. Majid; J. Sundarakumar; H.M. Gonzalez; M.I. Geerlings; I. Skoog; A. Salmoiraghi; F.M. Boneschi; V.N. Patel; J.M. Santos; G.R. Arroyo; A.C. Moreno; P. Felix; C. Gallo; H. Arai; M. Yamada; T. Iwatsubo; M. Sharma; N. Chakraborty; C. Ferreccio; D. Akena; C. Brayne; G. Maestre; S.W. Blangero; L.I. Brusco; P. Siddarth; T.M. Hughes; A.R. Zuñiga; J. Kambeitz; A.R. Laza; N. Allen; S. Panos; D. Merrill; A. Ibáñez; D. Tsuang; N. Valishvili; S. Shrestha; S. Wang; V. Padma; K.J. Anstey; V. Ravindrdanath; K. Blennow; P. Mullins; E. Łojek; A. Pria; T.H. Mosley; P. Gowland; T.D. Girard; R. Bowtell; F.S. Vahidy

doi:10.1002/trc2.12348

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Chronic neuropsychiatric sequelae of SARS‐CoV‐2: Protocol and methods from the Alzheimer's Association Global Consortium: Protocol and methods from the Alzheimer's Association Global Consortium

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Chronic neuropsychiatric sequelae of SARS‐CoV‐2: Protocol and methods from the Alzheimer's Association Global Consortium: Protocol and methods from the Alzheimer's Association Global Consortium

G.A. de Erausquin, H. Snyder, T.S. Brugha, S. Seshadri, M. Carrillo, R. Sagar, Y. Huang, C. Newton, C. Tartaglia, C. Teunissen, …

Alzheimer's & Dementia: Translational Research & Clinical Interventions, Vol.8(1), e12348

2022

DOI: https://doi.org/10.1002/trc2.12348

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Abstract

Introduction Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term. Methods This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions. Results Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe. Discussion The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection.

Details

Title: Chronic neuropsychiatric sequelae of SARS‐CoV‐2: Protocol and methods from the Alzheimer's Association Global Consortium
Authors/Creators: G.A. de Erausquin (Author/Creator)
H. Snyder (Author/Creator)
T.S. Brugha (Author/Creator)
S. Seshadri (Author/Creator)
M. Carrillo (Author/Creator)
R. Sagar (Author/Creator)
Y. Huang (Author/Creator)
C. Newton (Author/Creator)
C. Tartaglia (Author/Creator)
C. Teunissen (Author/Creator)
K. Håkanson (Author/Creator)
R. Akinyemi (Author/Creator)
K. Prasad (Author/Creator)
G. D'Avossa (Author/Creator)
G. Gonzalez‐Aleman (Author/Creator)
A. Hosseini (Author/Creator)
G.D. Vavougios (Author/Creator)
P. Sachdev (Author/Creator)
J. Bankart (Author/Creator)
N.P.O. Mors (Author/Creator)
R. Lipton (Author/Creator)
M. Katz (Author/Creator)
P.T. Fox (Author/Creator)
M.Z. Katshu (Author/Creator)
M.S. Iyengar (Author/Creator)
G. Weinstein (Author/Creator)
H.R. Sohrabi (Author/Creator)
R. Jenkins (Author/Creator)
D.J. Stein (Author/Creator)
J. Hugon (Author/Creator)
V. Mavreas (Author/Creator)
J. Blangero (Author/Creator)
C. Cruchaga (Author/Creator)
M. Krishna (Author/Creator)
O. Wadoo (Author/Creator)
R. Becerra (Author/Creator)
I. Zwir (Author/Creator)
W.T. Longstreth (Author/Creator)
G. Kroenenberg (Author/Creator)
P. Edison (Author/Creator)
E. Mukaetova‐Ladinska (Author/Creator)
E. Staufenberg (Author/Creator)
M. Figueredo‐Aguiar (Author/Creator)
A. Yécora (Author/Creator)
F. Vaca (Author/Creator)
H.P. Zamponi (Author/Creator)
V.L. Re (Author/Creator)
A. Majid (Author/Creator)
J. Sundarakumar (Author/Creator)
H.M. Gonzalez (Author/Creator)
M.I. Geerlings (Author/Creator)
I. Skoog (Author/Creator)
A. Salmoiraghi (Author/Creator)
F.M. Boneschi (Author/Creator)
V.N. Patel (Author/Creator)
J.M. Santos (Author/Creator)
G.R. Arroyo (Author/Creator)
A.C. Moreno (Author/Creator)
P. Felix (Author/Creator)
C. Gallo (Author/Creator)
H. Arai (Author/Creator)
M. Yamada (Author/Creator)
T. Iwatsubo (Author/Creator)
M. Sharma (Author/Creator)
N. Chakraborty (Author/Creator)
C. Ferreccio (Author/Creator)
D. Akena (Author/Creator)
C. Brayne (Author/Creator)
G. Maestre (Author/Creator)
S.W. Blangero (Author/Creator)
L.I. Brusco (Author/Creator)
P. Siddarth (Author/Creator)
T.M. Hughes (Author/Creator)
A.R. Zuñiga (Author/Creator)
J. Kambeitz (Author/Creator)
A.R. Laza (Author/Creator)
N. Allen (Author/Creator)
S. Panos (Author/Creator)
D. Merrill (Author/Creator)
A. Ibáñez (Author/Creator)
D. Tsuang (Author/Creator)
N. Valishvili (Author/Creator)
S. Shrestha (Author/Creator)
S. Wang (Author/Creator)
V. Padma (Author/Creator)
K.J. Anstey (Author/Creator)
V. Ravindrdanath (Author/Creator)
K. Blennow (Author/Creator)
P. Mullins (Author/Creator)
E. Łojek (Author/Creator)
A. Pria (Author/Creator)
T.H. Mosley (Author/Creator)
P. Gowland (Author/Creator)
T.D. Girard (Author/Creator)
R. Bowtell (Author/Creator)
F.S. Vahidy (Author/Creator)
Publication Details: Alzheimer's & Dementia: Translational Research & Clinical Interventions, Vol.8(1), e12348
Publisher: Wiley Periodicals LLC on behalf of Alzheimer’s Association
Identifiers: 991005542355707891
Murdoch Affiliation: Centre for Healthy Ageing
Language: English
Resource Type: Journal article

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