Journal article
Circulating microRNAs as biomarkers of alzheimer's disease: A systematic review
Journal of Alzheimer's disease : JAD, Vol.49(3), pp.755-766
2015
Abstract
Background: In recent years, microRNAs (miRNA), a class of non-coding RNA known to regulate protein expression posttranscriptionally, have been recognized as novel biomarkers of diseases. Objective: In this systematic review, we identify miRNAs that are differentially expressed in Alzheimer's disease (AD) and/or mild cognitive impairment (MCI) and evaluate their accuracy as potential blood biomarkers. Methods: Eligible studies of miRNAs in peripheral blood distinguishing patients with AD or MCI from cognitively normal controls were identified through standardized search strategies in Medline, PubMed, and Embase. MiRNAs that were differentially expressed were identified and where available their sensitivity and specificity for AD or MCI extracted from the retrieved studies. Results: Eighteen studies investigated the diagnostic value of miRNAs as peripheral biomarkers of AD/MCI. Twenty miRNAs were significantly upregulated and 32 miRNAs downregulated in AD compared to controls in ten AD studies. Nine miRNAs were consistently dysregulated in more than one study. Of the 8 MCI studies, only one miRNA, miR-132, was consistently upregulated in three independent studies. Of the studies that reported diagnostic accuracy data, the majority of miRNA panels and individual miRNAs had a sensitivity and specificity greater than 0.75. Conclusion: Individual studies suggest that miRNAs can differentiate patients with AD/MCI from cognitively normal controls with modest accuracy. However, the literature is constrained by methodological differences between studies, with few studies assessing the same miRNAs. To become potential biomarkers for AD, further studies with standardized study designs for replication and validation are required. Results from this review may help researchers select candidate miRNAs for further investigation.
Details
- Title
- Circulating microRNAs as biomarkers of alzheimer's disease: A systematic review
- Authors/Creators
- H.Z.Y. Wu (Author/Creator)K.L. Ong (Author/Creator)K. Seeher (Author/Creator)N.J. Armstrong (Author/Creator)A. Thalamuthu (Author/Creator)H. Brodaty (Author/Creator)P. Sachdev (Author/Creator)K. Mather (Author/Creator)M. Hornberger (Author/Creator)
- Publication Details
- Journal of Alzheimer's disease : JAD, Vol.49(3), pp.755-766
- Publisher
- IOS Press
- Identifiers
- 991005545005607891
- Copyright
- © 2016 - IOS Press and the authors.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.196 Micro & Long Noncoding RNA
- 1.196.68 MicroRNA in Cancer
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior