Journal article
Cisplatin: synthesis of some 2,3-diaminopropionic ester analogues: dichloro(hexadecyl 2,3-diaminopropionato) platinum(II) and dichloro(cyclohexyl 2,3-diaminopropionato) platinum(II)
South African Journal of Chemistry, Vol.40(2), pp.149-152
1987
Abstract
The title compounds were prepared from ethyl cyanoacetate by the four-step procedure of conversion into the corresponding 2-hydroxyimino-derivative, transesterification with either hexadecanol or cyclohexanol, catalytic hydrogenation of the respective products to afford the diamino-dihydrochlorides, and complex formation of the latter pair with potassium tetrachloroplatinate. Assignment of the structures of the cis-platinum complexes was confirmed by infrared spectrometry.
Details
- Title
- Cisplatin: synthesis of some 2,3-diaminopropionic ester analogues: dichloro(hexadecyl 2,3-diaminopropionato) platinum(II) and dichloro(cyclohexyl 2,3-diaminopropionato) platinum(II)
- Authors/Creators
- S.C. York (Author/Creator)D.B. Firfiray (Author/Creator)R.G.F. Giles (Author/Creator)D.A. Thorton (Author/Creator)G.M. Watkins (Author/Creator)
- Publication Details
- South African Journal of Chemistry, Vol.40(2), pp.149-152
- Publisher
- South African Bureau for Scientific Publications
- Identifiers
- 991005545204107891
- Copyright
- © 1987 South African Chemical Institute (SACI)
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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