Journal article
Cleavage and protection of locked nucleic acid–modified DNA by restriction endonucleases
Bioorganic & Medicinal Chemistry Letters, Vol.22(14), pp.4836-4838
2012
Abstract
Locked nucleic acid (LNA) is one of the most prominent nucleic acid analogues reported so far. We herein for the first time report cleavage by restriction endonuclease of LNA-modified DNA oligonucleotides. The experiments revealed that RsaI is an efficient enzyme capable of recognizing and cleaving LNA-modified DNA oligonucleotides. Furthermore, introduction of LNA nucleotides protects against cleavage by the restriction endonucleases PvuII, PstI, SacI, KpnI and EcoRI.
Details
- Title
- Cleavage and protection of locked nucleic acid–modified DNA by restriction endonucleases
- Authors/Creators
- L. Crouzier (Author/Creator) - The University of QueenslandC. Dubois (Author/Creator) - The University of QueenslandJ. Wengel (Author/Creator) - University of Southern DenmarkR.N. Veedu (Author/Creator) - The University of Queensland
- Publication Details
- Bioorganic & Medicinal Chemistry Letters, Vol.22(14), pp.4836-4838
- Publisher
- Elsevier BV
- Identifiers
- 991005543076407891
- Copyright
- © 2012 Elsevier Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.42 Bacteriology
- 1.42.131 Bacterial Gene Regulation
- Web Of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic
- ESI research areas
- Chemistry