Journal article
Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update
Clinical Pharmacology & Therapeutics, Vol.103(4), pp.574-581
2018
Abstract
The variant allele HLA‐B*15:02 is strongly associated with greater risk of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele HLA‐A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on HLA genotypes.
Details
- Title
- Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update
- Authors/Creators
- E.J. Phillips (Author/Creator)C. Sukasem (Author/Creator)M. Whirl-Carrillo (Author/Creator)D.J. Müller (Author/Creator)H.M. Dunnenberger (Author/Creator)W. Chantratita (Author/Creator)B. Goldspiel (Author/Creator)Y-T Chen (Author/Creator)B.C. Carleton (Author/Creator)A.L. George (Author/Creator)T. Mushiroda (Author/Creator)T. Klein (Author/Creator)R.S. Gammal (Author/Creator)M. Pirmohamed (Author/Creator)
- Publication Details
- Clinical Pharmacology & Therapeutics, Vol.103(4), pp.574-581
- Publisher
- Nature Publishing Group
- Identifiers
- 991005543781107891
- Copyright
- © 2018 American Society for Clinical Pharmacology and Therapeutics
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- 1.265 Dermatology - Skin Allergies
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