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CC BY V4.0, Open Access
Journal article
Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series
Animals (Basel), Vol.13(12), 2040
2023
Abstract
Thawed plasma (TP) refers to defrosted fresh frozen plasma stored refrigerated. TP is used in human medicine for the rapid provision of coagulation factors and resuscitation of haemorrhagic shock, but its use in dogs is poorly described. The objectives of this historical case series were to describe the reasons for TP transfusion, treatment outcomes, and adverse events associated with canine TP transfusions in a veterinary teaching hospital. We hypothesised that TP would be used most commonly for the treatment of haemorrhage secondary to anticoagulant rodenticide intoxication and trauma. Blood bank plasma transfusion logs were searched to identify dogs that received at least one unit of TP between December 2015 and June 2021. Briefly, 166 dogs received a total of 262 units of TP. Anticoagulant rodenticide intoxication (37/166, 22.3%) was the most common reason for transfusion, followed by traumatic haemorrhage (23, 13.9%) and spontaneous haemoperitoneum (22, 13.2%). The majority of dogs received one unit of TP (111/166, 67.1%) and pRBCs were commonly simultaneously transfused with TP (65, 39.2%). Severe prolongations of prothrombin time and activated partial thromboplastin time were reduced following TP transfusions. Allergic reactions were the most common transfusion reaction (19/166, 11.4%). Most dogs survived to discharge (101/166, 60.8%).
Details
- Title
- Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series
- Authors/Creators
- Weiqin Chee - Murdoch UniversityClaire R. Sharp - Murdoch UniversityCorrin J. Boyd - Murdoch University
- Publication Details
- Animals (Basel), Vol.13(12), 2040
- Publisher
- MDPI
- Identifiers
- 991005589652107891
- Copyright
- © 2023 by the authors
- Murdoch Affiliation
- Centre for Terrestrial Ecosystem Science and Sustainability; School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.75 Blood Clotting
- 1.75.324 Transfusion
- Web Of Science research areas
- Agriculture, Dairy & Animal Science
- Veterinary Sciences
- Zoology
- ESI research areas
- Plant & Animal Science