Journal article
Clinical and evolutionary consequences of HIV adaptation to HLA: implications for vaccine and cure
Current Opinion in HIV and AIDS, Vol.14(3), pp.194-204
2019
Abstract
Purpose of review
The purpose of this review is to summarize recent advances in our understanding of HIV adaptation to human leukocyte antigen (HLA)-associated immune pressures and its relevance to HIV prevention and cure research.
Recent findings
Recent research has confirmed that HLA is a major driver of individual and population-level HIV evolution, that HIV strains are adapting to the immunogenetic profiles of the different human ethnic groups in which they circulate, and that HIV adaptation has substantial clinical and immunologic consequences. As such, adaptation represents a major challenge to HIV prevention and cure. At the same time, there are opportunities: Studies of HIV adaptation are revealing why certain HLA alleles are protective in some populations and not others; they are identifying immunogenic viral epitopes that harbor high mutational barriers to escape, and they may help illuminate novel, vaccine-relevant HIV epitopes in regions where circulating adaptation is extensive. Elucidation of HLA-driven adapted and nonadapted viral forms in different human populations and HIV subtypes also renders ‘personalized’ immunogen selection, as a component of HIV cure strategies, conceptually feasible.
Summary
Though adaptation represents a major challenge to HIV prevention and cure, achieving an in-depth understanding of this phenomenon can help move the design of such strategies forward.
Details
- Title
- Clinical and evolutionary consequences of HIV adaptation to HLA: implications for vaccine and cure
- Authors/Creators
- S. Avila-Rios (Author/Creator) - Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico.J.M. Carlson (Author/Creator) - Microsoft (United States)M. John (Author/Creator) - Murdoch UniversityS. Mallal (Author/Creator) - Vanderbilt University Medical CenterZ.L. Brumme (Author/Creator) - Simon Fraser University
- Publication Details
- Current Opinion in HIV and AIDS, Vol.14(3), pp.194-204
- Publisher
- Lippincott Williams and Wilkins
- Identifiers
- 991005543691207891
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
53 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Immunology
- Infectious Diseases
- ESI research areas
- Immunology