Journal article
Clinical and immunogenetic correlates of abacavir hypersensitivity
AIDS, Vol.19(9), pp.979-981
2005
Abstract
A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CD8 proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.
Details
- Title
- Clinical and immunogenetic correlates of abacavir hypersensitivity
- Authors/Creators
- E.J. Phillips (Author/Creator)G. Wong (Author/Creator)R. Kaul (Author/Creator)K. Shahabi (Author/Creator)D. Nolan (Author/Creator)S.R. Knowles (Author/Creator)A.M. Martin (Author/Creator)S. Mallal (Author/Creator)N.H. Shear (Author/Creator)
- Publication Details
- AIDS, Vol.19(9), pp.979-981
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Identifiers
- 991005541611807891
- Copyright
- © 2005 Lippincott Williams & Wilkins, Inc.
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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