Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia

W. Qiu; J-S Wu; A. Castley; I. James; J. Joseph; F.T. Christiansen; W.M. Carroll; F.L. Mastaglia; A.G. Kermode

doi:10.1016/j.jocn.2009.12.011

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Journal article

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Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia

W. Qiu, J-S Wu, A. Castley, I. James, J. Joseph, F.T. Christiansen, W.M. Carroll, F.L. Mastaglia and A.G. Kermode

Journal of Clinical Neuroscience, Vol.17(8), pp.1009-1013

2010

DOI: https://doi.org/10.1016/j.jocn.2009.12.011

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Abstract

We aimed to characterize the clinical profile and human leukocyte antigen (HLA)-DRB1 genotype of patients with late onset multiple sclerosis (LOMS) in Western Australia. The clinical features, laboratory studies and HLA-DRB1 alleles were analysed in patients with multiple sclerosis (MS) with onset over 50 years of age and compared with 100 patients with early onset MS (EOMS). Of a cohort of 829 patients with MS, 73 (8.8%) presented at over 50 years of age, including 14 (1.7%) over 60 years. Patients with LOMS had a lower female to male ratio, more frequent initial motor dysfunction, less frequent sensory symptoms and optic neuritis, a more frequent primary-progressive course and shorter time to reach Extended Disability Status Scale (EDSS) scores of 3.0 and 6.0. More LOMS patients were initially misdiagnosed compared to patients with EOMS. HLA-DRB1*1501 was strongly associated with both LOMS and EOMS compared to the Control subjects, while HLA-DRB1*0801 was over-represented in patients with LOMS. We concluded that patients with LOMS have a different clinical profile when compared to those with EOMS. Carriers of HLA-DRB1*0801 may be more prone to develop MS at a later age.

Details

Title: Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia
Authors/Creators: W. Qiu (Author/Creator) - The University of Western Australia
J-S Wu (Author/Creator) - The University of Western Australia
A. Castley (Author/Creator) - Royal Perth Hospital
I. James (Author/Creator) - Royal Perth Hospital
J. Joseph (Author/Creator) - The University of Western Australia
F.T. Christiansen (Author/Creator) - Royal Perth Hospital
W.M. Carroll (Author/Creator)
F.L. Mastaglia (Author/Creator) - The University of Western Australia
A.G. Kermode (Author/Creator) - Sir Charles Gairdner Hospital
Publication Details: Journal of Clinical Neuroscience, Vol.17(8), pp.1009-1013
Publisher: Churchill Livingstone
Identifiers: 991005544647007891
Copyright: © 2010 Elsevier Ltd.
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior