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Clostridium difficile-associated diarrhoea
Journal article   Peer reviewed

Clostridium difficile-associated diarrhoea

B. Elliott, B.J. Chang, C.L. Golledge and T.V. Riley
Internal Medicine Journal, Vol.37(8), pp.561-568
2007
DOI: https://doi.org/10.1111/j.1445-5994.2007.01403.x
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Abstract

Clostridium difficile is an important nosocomial pathogen and the most frequently diagnosed cause of infectious hospital-acquired diarrhoea. Toxigenic strains usually produce toxin A and toxin B, which are the primary virulence factors of C. difficile. Some recently described strains produce an additional toxin, an adenosine-diphosphate ribosyltransferase known as binary toxin, the role of which in pathogenicity is unknown. There has been concern about the emergence of a hypervirulent fluoroquinolone-resistant strain of C. difficile in North America and Europe. The use of fluoroquinolone antimicrobials appears to be acting as a selective pressure in the emergence of this strain. In this review, we describe the current state of knowledge about C. difficile as a cause of diarrhoeal illness.

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#3 Good Health and Well-Being

Source: InCites

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29 Record Views
77 Times Cited - Web of Science

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.120 Inflammatory Bowel Diseases & Infections
1.120.1133 Clostridium Infections
Web Of Science research areas
Microbiology
ESI research areas
Clinical Medicine
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