Journal article
Clostridium difficile–associated diarrhea: Epidemiological data from Western Australia associated with a modified antibiotic policy
Clinical Infectious Diseases, Vol.35(12), pp.1457-1462
2002
Abstract
The incidence of Clostridium difficile-associated diarrhea (CDAD) has increased dramatically in hospitals worldwide during the past 2 decades. In Western Australia, this increase was most obvious during the 1980s, when there was also an increase in the use of third-generation cephalosporin antibiotics. A study of the epidemiology of CDAD and the use of third-generation cephalosporins during 1993-2000 was undertaken. From 1993 through 1998, the incidence of CDAD remained relatively stable (2-3 cases per 1000 discharges annually). Then, a significant decrease in the incidence occurred, from 2.09 cases per 1000 discharges (95% confidence interval [CI], 1.71-2.47) in 1998 to 0.87 cases per 1000 discharges (95% CI, 0.63-1.11) in 1999 (P<.0001); this decrease persisted into 2000. A decrease in third-generation cephalosporin use occurred during the period of the study because of changes in the prescribing policy. These findings suggest that a reduction in the use of third-generation cephalosporins can reduce the occurrence of CDAD.
Details
- Title
- Clostridium difficile–associated diarrhea: Epidemiological data from Western Australia associated with a modified antibiotic policy
- Authors/Creators
- C. Thomas (Author/Creator) - The University of Western AustraliaM. Stevenson (Author/Creator) - The University of Western AustraliaD.J. Williamson (Author/Creator) - Sir Charles Gairdner HospitalT.V. Riley (Author/Creator) - The University of Western Australia
- Publication Details
- Clinical Infectious Diseases, Vol.35(12), pp.1457-1462
- Publisher
- Oxford University Press
- Identifiers
- 991005546356107891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.1133 Clostridium Infections
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Microbiology
- ESI research areas
- Immunology