Journal article
Cluster of TRIM genes in the human MHC class I region sharing the B30.2 domain
Tissue Antigens, Vol.61(1), pp.63-71
2003
Abstract
The major histocompatibility complex (MHC), a region of high gene density, contains a large number of genes relevant to the immune response, belonging to different multigenic families. We studied the genomic organization and polymorphism of a set of genes in the MHC class I region containing the tripartite motif (TRIM), consisting of a RING domain, B-box and coiled coil region, and a B30.2-like domain. A cluster of seven genes at 6p21.33 and two related family members telomeric of the cluster were characterized. All MHC-encoded TRIM-B30.2 genes showed moderate levels of polymorphism, affecting predominantly the RING and B-box domains. In terms of structure, the genes varied by the loss of partial and, in some cases, complete domains. They were strongly conserved in exons 2, 3 and 4, which form the coiled-coil region. The last exon, encoding the B30.2-like domain, is shared with the otherwise unrelated butyrophilin-like (BTN) genes, located 4.3 Mb telomeric of the TRIM-B30.2 cluster. The data are consistent with multiple, ancient duplications giving rise to a set of related genes.
Details
- Title
- Cluster of TRIM genes in the human MHC class I region sharing the B30.2 domain
- Authors/Creators
- M. Meyer (Author/Creator) - University of CambridgeS. Gaudieri (Author/Creator) - University of CambridgeD.A. Rhodes (Author/Creator) - University of CambridgeJ. Trowsdale (Author/Creator) - University of Cambridge
- Publication Details
- Tissue Antigens, Vol.61(1), pp.63-71
- Publisher
- Blackwell Publishing
- Identifiers
- 991005541264907891
- Copyright
- © John Wiley & Sons, Inc.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
- Cell Biology
- Immunology
- Pathology
- ESI research areas
- Molecular Biology & Genetics