Cohort Profile: The Western Australian Pregnancy Cohort (Raine) Study-Generation 2

Leon Straker; Jenny Mountain; Angela Jacques; Scott White; Anne Smith; Louis Landau; Fiona Stanley; John Newnham; Craig Pennell; Peter Eastwood

doi:10.1093/ije/dyw308

Back

Journal article

Open access

Peer reviewed

Cohort Profile: The Western Australian Pregnancy Cohort (Raine) Study-Generation 2

Leon Straker, Jenny Mountain, Angela Jacques, Scott White, Anne Smith, Louis Landau, Fiona Stanley, John Newnham, Craig Pennell and Peter Eastwood

International journal of epidemiology, Vol.46(5), pp.1384-1385J

2017

DOI: https://doi.org/10.1093/ije/dyw308

PMCID: PMC5837608

PMID: 28064197

Files and links (1)

url

Published View

Published (Version of Record) Open

Abstract

pregnancy

adolescent

adult

child

follow-up

genetics

Why was the cohort set up? The Western Australian Pregnancy Cohort (Raine) Study (www.rainestudy.org.au) was established 1989-1991 with the then stated purpose: to develop a large cohort of Western Australian children studied from 18 weeks’ gestation to ascertain the relative contributions of familial risk factors, fetal growth, placental development and environmental insults to outcome in infancy and to the precursors of adult morbidity. This cohort, with complete intrauterine, perinatal and childhood data, will enable evaluation of the interaction between these factors, subsequent lifestyle patterns and environmental exposures which contribute to ill health during life. Establishment of the cohort involved combining funding for ‘a randomised controlled trial of the influence of serial fetal ultrasounds on birth outcomes’ from the National Health and Medical Research Council of Australia2 and funding to investigate ‘the origins of disease in the fetus, the child and the young adult’ from the Raine Medical Research Foundation.1 The conceptual framework for the study was initially based around the developmental origins of health and disease, but has since evolved into a life-course framework taking into account the multiple interacting domains of genetics, phenotypes (cardiometabolic, respiratory, immunological, hormonal, musculoskeletal, psychological, vision and hearing, body composition and growth), behaviours (physical activity, sedentary behaviour, sleep, diet, drug use, risk taking), the environment (sunlight, chemical exposures, spatial environment) and other developmental outcomes (education, work).

Details

Title: Cohort Profile: The Western Australian Pregnancy Cohort (Raine) Study-Generation 2
Authors/Creators: Leon Straker - Curtin University
Jenny Mountain - School of Population Health, University of Western Australia, Perth, WA, Australia
Angela Jacques - The University of Western Australia
Scott White - King Edward Memorial Hospital
Anne Smith - Curtin University
Louis Landau - The University of Western Australia
Fiona Stanley - The Kids Research Institute Australia
John Newnham - Infant
Craig Pennell - Infant
Peter Eastwood - The University of Western Australia
Publication Details: International journal of epidemiology, Vol.46(5), pp.1384-1385J
Grant note: CIHR
Identifiers: 991005569336707891
Murdoch Affiliation: Ngangk Yira Institute for Change
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

75 Record Views

208 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Highly Cited Paper

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.72 Obstetrics & Gynecology; 1.72.1072 Perinatal Mental Health
Web Of Science research areas: Public, Environmental & Occupational Health
ESI research areas: Social Sciences, general